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Clin Exp Rheumatol:Framingham、ACC/AHA或QRISK3:哪一个适合系统性红斑狼疮的心血管风险评估?

2020-01-12 xiangting MedSci原创

与经典算法如Framingham和ACC/AHA相比,QRISK3将更多的SLE患者归类为未来10年出现CV疾病的高危人群。

这项研究目的是在一个系统性红斑狼疮(SLE)患者队列中,比较三种心血管CV)风险评估的算法,即FraminghamACC/AHAQRISK3

根据ACR标准招募连续性SLE患者。评估传统危险因素、正在进行的治疗、合并症和SLE特异性评估。对于既往没有心梗或卒中的患者,使用FraminghamACC/AHAQRISK3算法以估算未来10年发生CV疾病的个体风险。

招募的135名患者中,123名符合CV风险评估条件。Framingham指数报告的中位风险评分为4.7%(IQR 9.5–2.2),29名患者(23.6%)被认为是CV高危。ACC/AHA指数的中位风险评分为1.4%(IQR 4.5-0.7),其中17名患者高危(13.8%)。QRISK3的中位风险评分为6.2%(IQR 12.5–2.8),将44名患者(35.8%)分类为CV高危。对40岁以上受试者进行亚组分析证实,FraminghamACC/AHA的高危患者人数相同,而QRISK338名受试者分类为CV高危。

与经典算法如FraminghamACC/AHA相比,QRISK3将更多的SLE患者归类为未来10年出现CV疾病的高危人群。如果纵向数据能够证实其预测的准确性,QRISK3会成为早期发现相当一部分CV高危SLE患者的重要工具,而应用经典算法可能会低估该类人群。

原始出处:

M. Di Battista. Framingham, ACC/AHA or QRISK3: which is the best in systemic lupus erythematosus cardiovascular risk estimation? Clin Exp Rheumatol. 2019.

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    2020-01-14 zhaohui6731
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    2020-01-14 zhouqu_8

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