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Eur J Cancer Care:荟萃分析表明miR-146a rs2910164是胃癌发生的危险因素

2017-10-24 MedSci MedSci原创

既往研究探究了miR-146a rs2910164与胃癌(GC)发生风险之间的相关性,但结果尚未确定。 为了更准确的评估二者之间的关联,本研究进行了荟萃分析。研究人员检索了2014年7月之前PubMed和中国知网在线发布的相关文章。使用stat 11.0对进行荟萃分析。结果共选择了7个病例对照研究,包括3283例病例和4535例对照者。所有遗传模型(CC VS. GG,OR = 0.76,95%C

既往研究探究了miR-146a rs2910164与胃癌(GC)发生风险之间的相关性,但结果尚未确定。 为了更准确的评估二者之间的关联,本研究进行了荟萃分析。

研究人员检索了2014年7月之前PubMed和中国知网在线发布的相关文章。使用stat 11.0对进行荟萃分析。结果共选择了7个病例对照研究,包括3283例病例和4535例对照者。所有遗传模型(CC VS. GG,OR = 0.76,95%CI = 0.66-0.87;CC VS. GC + GG,OR = 0.84,95%CI = 0.71-0.99)中均发现rs2910164和GC风险之间存在明显的相关关系;CC + GC VS. GG,OR = 0.82,95%CI = 0.73-0.91)。种族亚组分析发现,亚洲人群中此种关联存在明显的统计差异。

总之,该荟萃分析表明miR-146a rs2910164是GC发生的危险因素。

原始出处:


Sun Y, Li M. Genetic polymorphism of miR-146a is associated with gastric cancer risk: a meta-analysis. Eur J Cancer Care (Engl). 2017 Mar;26(2). doi: 10.1111/ecc.12355. Epub 2015 Jul 23.

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    2018-02-27 smallant2002
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    2018-09-08 zhaojie88
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    2018-08-06 feifers
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    2017-10-24 1206d468m59(暂无昵称)

    学习了

    0

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    2017-10-24 清风拂面

    谢谢分享.学习了

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