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Caribou宣布CRISPR-Cas9在DNA修复领域新近进展

2016-08-22 佚名 生物谷

最近,华人科学家张锋与美国科学家Dr. Jennifer Doudna就CRISPR技术专利之争因为一封邮件而再起波澜。令人庆幸的是,法律层面的争夺似乎并未令CRISPR技术明显受限。最近,CRISPR技术领域的先驱Caribou公司就再次发布了他们在CRISPR-Cas9研究领域的最新进展。公司的研究团队发现了CRISPR-Cas9基因编辑技术在不同细胞系中的响应模式。公司在最新进展中表示,

最近,华人科学家张锋与美国科学家Dr. Jennifer Doudna就CRISPR技术专利之争因为一封邮件而再起波澜。令人庆幸的是,法律层面的争夺似乎并未令CRISPR技术明显受限。最近,CRISPR技术领域的先驱Caribou公司就再次发布了他们在CRISPR-Cas9研究领域的最新进展。公司的研究团队发现了CRISPR-Cas9基因编辑技术在不同细胞系中的响应模式。公司在最新进展中表示,研究人员在利用该技术剪切了人类基因组中多达223个不同的位点。

Cas9是一种RNA引导的DNA内切酶。研究人员发现经过Cas9的剪切,细胞能够重新进入增殖阶段。同时,他们还指出,这种效果与特定的剪切靶点序列有关,而与被剪切的基因组信息无关。研究人员希望未来这一结果能够有助于进行基因敲除方面的工作。

Caribou公司CSO Andrew May表示这一发现在CRISPR-Cas9技术发展中有着深远影响。通过对DNA修复机制的研究,我们可以更深刻理解细胞内DNA编辑的原理。同时,这一研究还有望延伸到除了标准细胞系以外的细胞类型,如直接从组织中提取的初代细胞中。

Caribou公司今年五月份刚刚完成总额达3000万美元的B轮融资。其投资者包括多个著名投资公司,其中制药巨头诺华公司也出现在名单里。Caribou公司是由Dr. Jennifer Doudna支持创立的技术公司,可以说这一公司基本上代表了CRISPR技术研究领域的最高水平。与之相对的,华人科学家张锋则支持创立了Editas。

几乎就在同一时间,一封据称是来自张锋实验室前工作人员的邮件曝光,引起了业界广泛关注。该邮件认为,张锋在CRISPR技术领域的研究成果借鉴了Dr. Jennifer Doudna的研究。不过,这封邮件的可信性遭到了张锋所在的博德研究中心的否认。

原始出处

Caribou claims CRISPR-Cas9 advance on DNA repair

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    2016-08-24 yuandd
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    2016-08-24 respect
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    2016-08-24 jambiya
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    2016-08-24 yaanren

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