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JAMA Neurol:非痴呆人群脑淀粉样病变阳性率及其临床进展

2018-05-03 zhangfan MedSci原创

研究对非痴呆人群脑淀粉样病变阳性率及其临床进展进行考察,该研究对理解AD病理生理过程提供了指导

脑淀粉样沉积是阿尔茨海默病(AD) 的病理标志,非痴呆人群脑淀粉样病变研究对AD的预防和认识加深十分关键。近日研究人员考察了非痴呆人群淀粉样病变阳性率及其临床结果。

基线非痴呆人群参与研究,基线及每15个月进行一次临床及认知评估,同时接受碳-11-匹特堡复合物正电子发射断层成像(PET)研究。定义患者PET标准化摄取值比>1.42为淀粉样病变阳性。研究的主要终点是非痴呆人群淀粉样病变阳性率,考察参与者无痴呆症状至遗忘性轻度认知障碍(aMCI)以及aMCI或MCI(轻度认知障碍)至AD痴呆的进展过程。

总计3894名参与者,其中1671人接受PET检查,平均年龄71.3岁,男性占53.4%,MCI率约为10.7%。50-59岁非痴呆非认知障碍人群,淀粉样病变阳性率为2.7%,而80-89人群则上升至41.3%。50-59岁非痴呆MCI人群的淀粉样病变阳性率为0%,而80-89岁则上升至16.4%。淀粉样病变阳性的非认知障碍人群相对于阴性人群,其aMCI风险增加2倍(HR 2.26, 95%,CI,1.52-3.35)。淀粉样病变阳性的MCI人群相对于阴性人群其AD痴呆风险增加1.86倍。淀粉样病变阳性的aMCI人群其AD痴呆风险增加2.56倍。随访期间淀粉样病变阳性人群总体认知和记忆领域Z评分显著下降。随访发现,对于基线非痴呆人群,其无症状至aMCI过程平均花费3.7年,而aMCI或MCI发展至AD痴呆需要3.8年。

研究对非痴呆人群脑淀粉样病变阳性率及其临床进展进行考察,该研究对理解AD病理生理过程提供了指导。

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    2018-07-20 yinhl1978
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    2018-05-03 131****1460

    学习了受益匪浅

    0

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    2018-05-03 三生有幸9135

    学习一下谢谢分享

    0

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    2018-05-03 zdvfsadb

    学习了

    0

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