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Oncogene:NRP-1在使用雄激素靶向治疗前列腺肿瘤患者中可以预测转移和死亡率

2017-01-24 MedSci MedSci原创

Oncogene:NRP-1在使用雄激素靶向治疗前列腺肿瘤患者中可以预测转移和死亡率最近的研究证据提示跨膜共受体神经纤毛蛋白-1(NRP1)在癌症进展中扮演一定的角色。NRP-1主要是神经元和血管生成的调节器,此外,其也在多种人类恶性肿瘤中表达,并且它可以促进肿瘤血管的生成。然而,NRP-1在肿瘤进展中的非血管生成作用仍然不甚明了。近期,一项发表在Oncogene杂志上的文章显示:NRP-1作为雄

Oncogene:NRP-1在使用雄激素靶向治疗前列腺肿瘤患者中可以预测转移和死亡率

最近的研究证据提示跨膜共受体神经纤毛蛋白-1(NRP1)在癌症进展中扮演一定的角色。NRP-1主要是神经元和血管生成的调节器,此外,其也在多种人类恶性肿瘤中表达,并且它可以促进肿瘤血管的生成。然而,NRP-1在肿瘤进展中的非血管生成作用仍然不甚明了。

近期,一项发表在Oncogene杂志上的文章显示:NRP-1作为雄激素抑制基因,其表达在前列腺肿瘤患者使用雄激素靶向治疗(ATT)期间升高,并且进展到转移性去势抵抗性前列腺癌(mCRPC)。

此项研究使用短发夹RNA(shRNA)介导抑制NRP1,研究证明NRP-1调节间质表型的mCRPC细胞模型和肿瘤细胞在体内的侵袭性和转移性传播。

在体试验中,使用组织微阵列和mRNA表达分析的免疫组织化学染色显示NRP-1表达与Gleason分级增加、病理T评分、淋巴结阳性状态和主要治疗失败之间具有正相关性。

此外,几个大型临床前列腺癌(PCa)队列的多变量分析确定根治性前列腺切除术的NRP-1表达可以作为放射治疗、肿瘤转移和癌症特异性死亡率之后的生化复发的独立预后生物标志物。

这项研究首次确定NRP-1作为新型雄激素抑制基因在使用ATTs治疗前列腺癌患者期间反应性应答的上调,其是临床转移和致死PCa的预后生物标志物的适应性反应。

原始出处:
Tse BW1, Volpert M1, Ratther E, et al. Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality. Oncogene. 2017 Jan 16. doi: 10.1038/onc.2016.482.

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    2017-05-13 cy0324
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    2017-01-26 zsyan
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    2017-01-25 1dd8aa01m06(暂无匿称)

    学习了,很好的内容

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1771463, encodeId=2c4d1e714635a, content=<a href='/topic/show?id=3e0432563e5' target=_blank style='color:#2F92EE;'>#前列腺肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32563, encryptionId=3e0432563e5, topicName=前列腺肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=257238300920, createdName=gous, createdTime=Mon Apr 03 05:22:00 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2048767, encodeId=c29a2048e6795, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Sat May 13 01:22:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424176, encodeId=1a7a14241e6c2, content=<a href='/topic/show?id=94c182929d0' target=_blank style='color:#2F92EE;'>#肿瘤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82929, encryptionId=94c182929d0, topicName=肿瘤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=60943920553, createdName=lanyan20020087, createdTime=Thu Jan 26 05:22:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558056, encodeId=929e155805655, content=<a href='/topic/show?id=2f1c13349e7' target=_blank style='color:#2F92EE;'>#Oncogene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13349, encryptionId=2f1c13349e7, topicName=Oncogene)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=154614942533, createdName=zsyan, createdTime=Thu Jan 26 05:22:00 CST 2017, time=2017-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172447, encodeId=28321e2447e8, content=学习了,很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Wed Jan 25 03:33:36 CST 2017, time=2017-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172438, encodeId=4c721e24387d, content=啊(⊙o⊙), beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b592012715, createdName=1e1f3b8dm20(暂无匿称), createdTime=Wed Jan 25 00:17:45 CST 2017, time=2017-01-25, status=1, ipAttribution=)]
    2017-01-25 1e1f3b8dm20(暂无匿称)

    啊(⊙o⊙)

    0

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