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Curr Biol:科学家发现控制女性生育能力的生物钟

2014-11-03 佚名 生物谷

有些女性甚至在50岁的时候都可以成功妊娠,然而有些女性却在30岁时就已经不能怀孕了,近日,来自哥德堡大学的科学家就对此现象进行了分析研究,其中一种影响因素就是女性绝经期的开始会被其机体卵细胞的释放所影响,相关研究刊登于国际杂志Current Biology上。由此研究者便揭开了控制女性生育能力的生物钟,正如新生儿需要营养物来生存一样,子宫中的卵细胞也需要来自初级卵泡颗粒细胞的营养补给,文章中研究人

有些女性甚至在50岁的时候都可以成功妊娠,然而有些女性却在30岁时就已经不能怀孕了,近日,来自哥德堡大学的科学家就对此现象进行了分析研究,其中一种影响因素就是女性绝经期的开始会被其机体卵细胞的释放所影响,相关研究刊登于国际杂志Current Biology上。

由此研究者便揭开了控制女性生育能力的生物钟,正如新生儿需要营养物来生存一样,子宫中的卵细胞也需要来自初级卵泡颗粒细胞的营养补给,文章中研究人员在颗粒细胞中发现了一种信号通路或许可以使未成熟的卵细胞存活下来。

颗粒细胞中的mTOR信号通路对于受体配体生长因子的激活表达非常必要,受体配体生长因子随后可以结合卵细胞中的c-kit受体从而决定卵细胞的命运。研究者Liu说道,这种机制就可以使得颗粒细胞决定卵细胞何时开始生长以及何时死亡,从这个层面意义上来讲,颗粒细胞就会为卵细胞提供一种生物钟,来监测女性更年期的发生。

研究人员认为本文研究或可通过干预的方法来刺激不能成熟的卵细胞生长,而后期研究者就可以利用这种机制来控制人类卵细胞的发育,开发出新型的疗法来治疗临床不孕症。

原始出处:


Hua Zhang, Sanjiv Risal, Nagaraju Gorre, Kiran Busayavalasa, Xin Li, Yan Shen, Benedikt Bosbach, Mats Brännström, Kui Liu.Somatic Cells Initiate Primordial Follicle Activation and Govern the Development of Dormant Oocytes in Mice.Curr Biol.DOI: http://dx.doi.org/10.1016/j.cub.2014.09.023

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    2014-12-19 hb2008ye
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