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Diabetic Med:冠状动脉计算机断层扫描血管造影评估新诊断的2型糖尿病冠状动脉斑块成分的性别差异与低度炎症的关联

2018-12-28 MedSci MedSci原创

近日,国际杂志 《Diabetic Med》上在线发表一项关于冠状动脉计算机断层扫描血管造影评估新诊断的2型糖尿病冠状动脉斑块成分的性别差异与低度炎症的关联的研究。本研究目的探讨新诊断的2型糖尿病患者与未发现心血管疾病的患者在冠状动脉斑块组成和炎症生物标志物方面的差异 共有88名新诊断(<1年)2型糖尿病患者接受了对比增强冠状动脉计算机断层扫描血管造影。使用半自动化软件进行高级冠状动

近日,国际杂志 《Diabetic Med》上在线发表一项关于冠状动脉计算机断层扫描血管造影评估新诊断2糖尿病冠状动脉斑块成分的性别差异与低度炎症的关联的研究。本研究目的探讨新诊断2糖尿病患者与未发现血管疾病的患者在冠状动脉斑块组成和炎症生物标志物方面的差异

共有88名新诊断(<1年)2糖尿病患者接受了对比增强冠状动脉计算机断层扫描血管造影。使用半自动化软件进行高级冠状动脉斑块分析。测定炎症生物标志物的血浆浓度。

结果显示,男性(n=60)和女性(n=28)在年龄或心血管危险因素方面无显著差异(均P>0.05)。中位数(四分位数)血清纤维蛋白原水平[10.99.8-12.6)μmol/ l vs 9.78.8-10.9)μmol/ l],纤维蛋白d-二聚体[0.30.2-0.4mg/l vs 0.270.2- 0.4 mg /l]C反应蛋白[3.11.1-5.2mg /l vs0.8-2.61.6 mg /l]显著高于女性(均P <0.05)。总体而言,男性更容易患多支血管[28名男性(47%)vs 4名女性(14%)]病症,总斑块负担较高[中位数(四分位数)11.62.3-36.0)%vs 2.00.4-5.4)%; P <0.05]。在男性中中位数(四分位数)总斑块体积[269.962.6-641.9mm3 vs 61.17.6-239.9mm3 ]和绝对钙化斑块体积[33.58.3-148.3mm 3 vs 4.70.9-17.3mm 3 ]较高(均P <0.05)。女性钙化斑块成分的相对比例较低[中位数(四分位数)7.84.7-15.4)%vs 23.78.4-31.1)%]和非低密度非小腿斑块成分相对比例较高(中位数[四分位数][77.666.0-86.0)%vs 63.654.0-72.9)%; P <0.05]

与男性相比较,在新诊断出的2型糖尿病患者中,女性的冠状动脉斑块绝对体积较低,但斑块成分较差,并全身炎症加重。

原始出处:

M. MrganJ. GramM. Hecht Olsenet al. Sex differences in coronary plaque composition evaluated by coronary computed tomography angiography in newly diagnosed Type 2 diabetes: association with lowgrade inflammation

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    2019-02-12 bioon14
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  5. 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  6. 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  7. 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createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Sun Dec 30 00:38:00 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609414, encodeId=04f2160941490, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 30 00:38:00 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
    2019-03-09 rgjl
  8. [GetPortalCommentsPageByObjectIdResponse(id=2005397, encodeId=2765200539e09, content=<a href='/topic/show?id=73002620458' target=_blank style='color:#2F92EE;'>#低度炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26204, encryptionId=73002620458, topicName=低度炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Jun 26 01:38:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694560, encodeId=b72f16945606e, content=<a href='/topic/show?id=8cc7308e239' target=_blank style='color:#2F92EE;'>#冠状动脉斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30872, encryptionId=8cc7308e239, topicName=冠状动脉斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, 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  9. [GetPortalCommentsPageByObjectIdResponse(id=2005397, encodeId=2765200539e09, content=<a href='/topic/show?id=73002620458' target=_blank style='color:#2F92EE;'>#低度炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26204, encryptionId=73002620458, topicName=低度炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Wed Jun 26 01:38:00 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694560, encodeId=b72f16945606e, content=<a href='/topic/show?id=8cc7308e239' target=_blank style='color:#2F92EE;'>#冠状动脉斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30872, encryptionId=8cc7308e239, topicName=冠状动脉斑块)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=null, createdBy=908d9134595, createdName=sodoo, createdTime=Sun Dec 30 00:38:00 CST 2018, time=2018-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609414, encodeId=04f2160941490, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Dec 30 00:38:00 CST 2018, time=2018-12-30, status=1, ipAttribution=)]
    2018-12-30 sodoo
  10. 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