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IJLH：低、高狼疮抗凝血敏感性的配对APTTs可区分其他异常，并与dRVVT联合应用可获得良好的狼疮抗凝血检出率

2019-06-02 不详 网络

狼疮抗凝血
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延长活化部分促凝血酶原激酶时间（APTT）可提示特定或多因子缺乏，治疗性抗凝，非特异性因子抑制剂或狼疮抗凝血剂（LA）的存在。最近，LA敏感的APTT和标准APTT试剂（Cephen LS和Cephen）的配对分别被证明在LA检测中是有效的。本研究旨在评估该试剂对用于区分APTT升高的原因和LA的检测以及稀释的Russell v蛇毒液时间（dRVVT）的有效性。 研究人员采用50例正常和10

延长活化部分促凝血酶原激酶时间（APTT）可提示特定或多因子缺乏，治疗性抗凝，非特异性因子抑制剂或狼疮抗凝血剂（LA）的存在。最近，LA敏感的APTT和标准APTT试剂（Cephen LS和Cephen）的配对分别被证明在LA检测中是有效的。本研究旨在评估该试剂对用于区分APTT升高的原因和LA的检测以及稀释的Russell v蛇毒液时间（dRVVT）的有效性。

研究人员采用50例正常和105例常规dRVVT和/或稀释APTT (dAPTT)的非抗凝血LA阳性患者的血浆样本，并采用百分率校正公式。采用头孢菌素LS/头孢菌素和dRVVT试剂LA1/LA2分别进行筛选/确认。使用34‐LA‐阴性症状，25‐华法化非抗磷脂综合征，6种凝血抑制剂，17例遗传性APTT升高的样本，24例FVIII/IX/XI/XII和17例FII/V/X人工单缺陷等离子体。

研究显示，105个样本中有33个(31%)在头孢菌素LS/头孢菌素中呈LA‐阳性。与常规dRVVT/dAPTT双阳性相比，头孢素LS/头孢素和LA1/LA2对的总阳性率为89.1%。常规dAPTT/dRVVT阳性组头孢尔酮LS/头孢尔酮纠正率明显高于其他各组。

研究表明，APTT试剂对的百分校正值在LA‐阳性样品中较高。该组合将有助于区分LA与其他异常样本，并在与dRVVT配对时有效地检测LA。

原始出处：

Osamu Kumano, Jean Amiral,Paired APTTs of low and high lupus anticoagulant sensitivity permit distinction from other abnormalities and achieve good lupus anticoagulant detection rates in conjunction with dRVVT

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    2020-01-21 s_pl2017

    #联合应用#

    0

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    2019-08-04 xiongke010

    #检出率#

    0

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    2019-08-06 respect

    #APTT#

    0

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    2019-06-04 sunrural_42825357

    #狼疮#

    0

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    2019-06-04 ms5236388012055669

    #敏感性#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1684178, encodeId=e4ff16841e875, content=<a href='/topic/show?id=7425806967a' target=_blank style='color:#2F92EE;'>#联合应用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80696, encryptionId=7425806967a, topicName=联合应用)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=091d28056243, createdName=s_pl2017, createdTime=Tue Jan 21 09:44:00 CST 2020, time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904807, encodeId=14d4190480ea8, content=<a href='/topic/show?id=ae97625036d' target=_blank style='color:#2F92EE;'>#检出率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62503, encryptionId=ae97625036d, topicName=检出率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ce68183, createdName=xiongke010, createdTime=Sun Aug 04 05:44:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1720599, encodeId=d4e41e2059980, content=<a href='/topic/show?id=c3142e0093' target=_blank style='color:#2F92EE;'>#APTT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2700, encryptionId=c3142e0093, topicName=APTT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c3f32877268, createdName=respect, createdTime=Tue Aug 06 06:44:00 CST 2019, time=2019-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387350, encodeId=2db9138e35047, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Tue Jun 04 06:44:00 CST 2019, time=2019-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1388452, encodeId=896513884520b, content=<a href='/topic/show?id=7ef25e5346b' target=_blank style='color:#2F92EE;'>#敏感性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Tue Jun 04 06:44:00 CST 2019, time=2019-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1447034, encodeId=74a8144e034e1, content=<a href='/topic/show?id=549489135c5' target=_blank style='color:#2F92EE;'>#血检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89135, encryptionId=549489135c5, topicName=血检)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cc1f5300484, createdName=Luyuxie_11, createdTime=Tue Jun 04 06:44:00 CST 2019, time=2019-06-04, status=1, ipAttribution=)]
    2019-06-04 Luyuxie_11

    #血检#

    0

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