Stem Cell Rep：科学家利用小鼠胚胎干细胞首次在体外成功构建了3D脊髓组织

2014-11-04 佚名生物谷

脊椎动物的神经系统源于神经管的发育所成，而神经管则是脊椎动物脊髓和大脑分化的基础，近日，来自德国德累斯顿工业大学等处的研究人员通过研究首次实现了利用小鼠胚胎干细胞在体外成功构建了三维的脊髓结构，相关研究成果刊登于国际杂志Stem Cell Reports上。很多年以来研究人员一直致力于在分子水平上研究墨西哥蝾螈的再生潜力，机体损伤后墨西哥蝾螈可以实现脊髓和其它器官的再生而且再生后的组织具有

脊椎动物的神经系统源于神经管的发育所成，而神经管则是脊椎动物脊髓和大脑分化的基础，近日，来自德国德累斯顿工业大学等处的研究人员通过研究首次实现了利用小鼠胚胎干细胞在体外成功构建了三维的脊髓结构，相关研究成果刊登于国际杂志Stem Cell Reports上。

很多年以来研究人员一直致力于在分子水平上研究墨西哥蝾螈的再生潜力，机体损伤后墨西哥蝾螈可以实现脊髓和其它器官的再生而且再生后的组织具有完全的功能。然而哺乳动物比如人类就不能实现机体器官的再生。墨西哥蝾螈脊髓的再生会形成和胚胎脊髓类似的三维结构，由于其在组织中的位置，再生脊髓中的功能性细胞就会在恢复的组织中发挥作用，这项研究中研究者将墨西哥蝾螈的机体再生潜能成功地运用到了哺乳动物机体中。

单一的小鼠胚胎干细胞可以嵌入到三维基质中，并且在神经分化的培养基中生长从而促进神经上皮包囊的发育，这些包囊会沿着神经轴在中脑和后脑中定植，而研究者的目标则是在体外实现脊髓的产生，研究者Andrea Meinhardt说道，为了达到目的我们将类维生素A加入到3D培养基中，其不仅可以促进神经组织转变成为脊髓，而且可以诱导信号中心的形成用于形成组成脊髓的所有不同的细胞类型。

本文中研究人员首次在体外成功构建了标准的胚胎神经管，而该研究也为后期成功构建三维结构的脊髓组织，用于在人类机体中移植脊髓治疗疾病提供了一定的希望和帮助。

原始出处

Andrea Meinhardt, Dominic Eberle, Akira Tazaki, Adrian Ranga, Marco Niesche, Michaela Wilsch-Bräuninger, Agnieszka Stec, Gabriele Schackert, Matthias Lutolf, Elly M. Tanaka.3D Reconstitution of the Patterned Neural Tube from Embryonic Stem Cells.Stem Cell Rep.2014

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2015-03-09 hb2008ye

#stem cell#

68 0
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2015-09-13 zhaozhouchifen

#Cell#

63 0
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2015-05-06 维他命

#CEL#

76 0
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2014-11-06 ailian1202

#胚胎#

65 0
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2014-11-06 ms9833124466084992

#3D#

82 0
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2014-11-06 zhaojie88

#胚胎干细胞#

84 0
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2014-11-06 12498bb3m92(暂无昵称)

#STEM#

70 0

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Stem Cell Rep：科学家利用小鼠胚胎干细胞首次在体外成功构建了3D脊髓组织

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