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Sci Rep:在前列腺癌中,骨形态生成蛋白-2表达的减少与生化复发相关

2018-08-08 AlexYang MedSci原创

最近,有研究人员在前列腺癌患者中利用免疫组化技术在前列腺癌组织中评估了BMP-2的表达的预后价值情况。研究人员在2007年7月到2010年8月之间,在患有局部前列腺癌(平均年龄,62.7岁;平均跟踪调查时间90.4个月)的90名患者的根治性前列腺切除样本中利用免疫组化技术评估了BMP-2的表达情况,并利用逐步多变量Cox回归模型分层方法评估了预测因素和评估的风险比(HRs)的独立效应。研究发现,在

最近,有研究人员在前列腺癌患者中利用免疫组化技术在前列腺癌组织中评估了BMP-2的表达的预后价值情况。

研究人员在2007年7月到2010年8月之间,在患有局部前列腺癌(平均年龄,62.7岁;平均跟踪调查时间90.4个月)的90名患者的根治性前列腺切除样本中利用免疫组化技术评估了BMP-2的表达情况,并利用逐步多变量Cox回归模型分层方法评估了预测因素和评估的风险比(HRs)的独立效应。研究发现,在BMP-2表达减少和正常BMP-2表达组之间,格林森得分(GS)和生化复发(BCR)具有显著的差异。单变量分析阐释了GS、T阶段(≥T3)和BMP-2表达的减少是BCR明显的预测决定性因素。另外,在多变量分析中,GS(7: HR 2.836, p=0.022; ≥8: HR 3.506, p=0.048)和BMP-2表达的减少(HR 2.007, p=0.047)与BCR显著相关。在BMP-2表达减少组中,5年总无BCR生存率要比正常表达组情况更差。

最后,研究人员指出,在前列腺癌患者中,BMP-2在前列腺癌组织中表达的减少与无BCR生存的预后因素相关。

原始出处:


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    2018-12-06 kafei

    了解一下谢谢

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=354613, encodeId=72fa35461399, content=了解一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Thu Dec 06 10:02:18 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340143, encodeId=776234014330, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b2e1935437, createdName=AlexYang, createdTime=Wed Aug 22 13:05:01 CST 2018, time=2018-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1384585, encodeId=432c13845851e, content=<a href='/topic/show?id=06e068891d4' target=_blank style='color:#2F92EE;'>#生化复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68891, encryptionId=06e068891d4, topicName=生化复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 10 10:56:00 CST 2018, time=2018-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337544, encodeId=257133e54420, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Thu Aug 09 12:49:24 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337376, encodeId=b9bb33e376f5, content=学习一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed Aug 08 22:21:44 CST 2018, time=2018-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337368, encodeId=50aa33e368a8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Aug 08 21:38:20 CST 2018, time=2018-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=337357, encodeId=101833e35754, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 08 20:59:55 CST 2018, time=2018-08-08, status=1, ipAttribution=)]
    2018-08-22 AlexYang

    好文章!

    0

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    2018-08-09 一个字-牛

    学习了谢谢分享

    0

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    2018-08-08 天地飞扬

    学习一下,谢谢分享!

    0

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    2018-08-08 医者仁心5538

    学习了

    0

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    2018-08-08 orangesking

    0

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