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JAHA:脂肪组织中亚油酸与缺血性卒中

2018-06-26 xing.T MedSci原创

由此可见,脂肪组织中亚油酸含量与总的缺血性卒中和大动脉粥样硬化引起的卒中风险成反比。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员调查了长期摄入亚油酸的生物标记脂肪组织中亚油酸含量与缺血性卒中及其亚型风险之间的关联。

饮食、癌症和健康的丹麦队列研究纳入了57053例入选时50至65岁的患者。所有参与者在入组时都进行了脂肪组织活检,而且从丹麦国家患者登记处获得了随访期间缺血性卒中的信息。根据Org 10172在急性卒中治疗(TOAST)分类的试验,卒中诊断全部得到验证和分类。病例和随机抽取的3500例患者的脂肪组织中脂肪酸组成是通过气相色谱法测定。研究人员使用加权Cox比例风险回归计算了风险比和95%可信区间。

在13.5年随访期间,研究人员确定了1879例缺血性卒中病例,其中有1755例可获得脂肪活检,而脂肪活组织检查可用于3203例亚组参与者。当比较脂肪组织中亚油酸含量最高和最低四分位数患者时,其与总缺血性卒中(风险比为0.78; 95%可信区间为0.65-0.93)和大动脉粥样硬化(风险比为0.61; 95%可信区间为0.43-0.88)发生率呈负相关,而与小血管阻塞存在负相关的迹象(风险比为0.87,95%可信区间0.69-1.11)。与心源性栓塞的发生率没有明确的相关性。

由此可见,脂肪组织中亚油酸含量与总的缺血性卒中和大动脉粥样硬化引起的卒中风险成反比。

原始出处:


Stine Krogh Venø.et al. Linoleic Acid in Adipose Tissue and Development of Ischemic Stroke: A Danish Case‐Cohort Study.JAHA.2018. https://doi.org/10.1161/JAHA.118.009820

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    2018-12-19 lingqf
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    2018-07-01 虈亣靌

    学习了.学习了.学习了

    0

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    2018-06-28 zhaohui6731
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1754008, encodeId=f1051e54008fb, content=<a href='/topic/show?id=c7562426580' target=_blank style='color:#2F92EE;'>#亚油酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24265, encryptionId=c7562426580, topicName=亚油酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c3136632776, createdName=lingqf, createdTime=Wed Dec 19 22:06:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806255, encodeId=68cc180625594, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 05 01:06:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893073, encodeId=345a18930e35d, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Mar 31 01:06:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328410, encodeId=5de43284105a, content=学习了.学习了.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jul 01 09:33:12 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267853, encodeId=66cc126e85380, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jun 28 11:06:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345768, encodeId=f8791345e683b, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Jun 28 11:06:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327255, encodeId=12bd32e25508, content=认真学习.把间接经验应用到临床实践中去.然后再总结出新思路.给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 26 23:57:03 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026087, encodeId=801d102608e7f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Jun 26 23:06:00 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 虈亣靌

    认真学习.把间接经验应用到临床实践中去.然后再总结出新思路.给点赞啦

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1754008, encodeId=f1051e54008fb, content=<a href='/topic/show?id=c7562426580' target=_blank style='color:#2F92EE;'>#亚油酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24265, encryptionId=c7562426580, topicName=亚油酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c3136632776, createdName=lingqf, createdTime=Wed Dec 19 22:06:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806255, encodeId=68cc180625594, content=<a href='/topic/show?id=b649e9358fa' target=_blank style='color:#2F92EE;'>#缺血性卒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79358, encryptionId=b649e9358fa, topicName=缺血性卒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Mar 05 01:06:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893073, encodeId=345a18930e35d, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sun Mar 31 01:06:00 CST 2019, time=2019-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328410, encodeId=5de43284105a, content=学习了.学习了.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jul 01 09:33:12 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267853, encodeId=66cc126e85380, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jun 28 11:06:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1345768, encodeId=f8791345e683b, content=<a href='/topic/show?id=f8c5843e3c5' target=_blank style='color:#2F92EE;'>#脂肪组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84373, encryptionId=f8c5843e3c5, topicName=脂肪组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=66962500501, createdName=yige2004, createdTime=Thu Jun 28 11:06:00 CST 2018, time=2018-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327255, encodeId=12bd32e25508, content=认真学习.把间接经验应用到临床实践中去.然后再总结出新思路.给点赞啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 26 23:57:03 CST 2018, time=2018-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026087, encodeId=801d102608e7f, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Jun 26 23:06:00 CST 2018, time=2018-06-26, status=1, ipAttribution=)]
    2018-06-26 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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近日,清华大学医学院、免疫所曾文文课题组于《Molecular Metabolism》杂志发表研究论文,报导脂肪组织内血管的全组织三维分布状态以及生理和病理条件下的变化趋势,并进一步揭示交感神经调控血管再生和可塑性特征的重要功能。

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