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Clinica Chimica Acta：MP-IgG定量检测对成人肺炎支原体肺炎的诊断价值

2020-04-13 MedSci原创 MedSci原创

成人；肺炎；支原体肺炎
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曾被广泛用于肺炎支原体(M.pneumoniae)抗体检测的被动颗粒凝集(PA)试验，现在已逐渐被定量酶联免疫吸附法(ELISA)所取代。然而，由于缺乏定量ELISA肺炎杆菌-IgG(MP-IgG)的

曾被广泛用于肺炎支原体(M.pneumoniae)抗体检测的被动颗粒凝集(PA)试验，现在已逐渐被定量酶联免疫吸附法(ELISA)所取代。然而，由于缺乏定量ELISA肺炎杆菌-IgG(MP-IgG)的诊断标准，以及ELISA肺炎杆菌-IgM(MP-IgM)的阳性率较低，限制了ELISA对成人肺炎杆菌感染的诊断价值。

在此，研究人员对肺炎支原体肺炎支原体肺炎（MP-IgG）在成人肺炎支原体肺炎（MPP）中的诊断价值进行了定量ELISA MP-IgG的评估。以PA结果为参考标准，在162例MPP患者、228例社区获得性肺炎(CAP)非肺炎支原体肺炎(NMP)患者和162例健康对照组患者中，通过ELISA法检测到血清M. 对于MP-IgM-/IgG+亚组，单次血清MP-IgG水平≥92.67 RU/mL可作为急性肺炎支原体感染的诊断参考标准。入院时，对于CAP患者，ELISA MP-IgM阳性的MPP的敏感性和特异性分别为18.51%和99.56%。MP-IgM阳性联合MP-IgG≥92.67 RU/mL，敏感性提高到40.12%，特异性降低到94.29%。对于7天内获得的配对血清样本，ELISA法MP-IgG浓度变化≥1.48倍，第7天MP-IgG≥92.67 RU/mL作为肺炎杆菌感染的诊断标准。

因此，ELISA法结合MP-IgM定性检测和MP-IgG定量检测对成人急性MPP的诊断具有重要价值。

原始出处：

Lina Wu，Maosheng Ye，Diagnostic value of quantitative MP-IgG for Mycoplasma pneumoniae pneumonia in adults

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    2020-10-28 medscijoin

    #诊断价值#

    0

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    2020-05-29 windight

    #CTA#

    0

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    2020-04-14 ms5906905816781247

    #支原体#

    0

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    2020-04-14 ms5768352621950538

    #IgG#

    0

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