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J Exp Med：靶向FSTL1-DIAPH1或可有效治疗上皮癌

2017-10-08 MedSci MedSci原创

FSTL1-DIAPH1上皮癌
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众所周知，上皮癌可延长伤口愈合程序，促进恶性转化。伤口的愈合需要通过双态分子开关激活角质细胞迁移。该开关涉及从单个转录物中产生抗迁移微小RNA miR-198或前体迁移性卵泡抑素样1（FSTL1）蛋白；健康皮肤中miR-198的表达下调，有利于FSTL1的产生，增强角质形成细胞迁移并促进再上皮化。本研究中，研究人员揭示了头颈鳞状细胞癌（HNSCC）中缺陷的分子开关。这种缺陷抑制了miR-198的表

众所周知，上皮癌可延长伤口愈合程序，促进恶性转化。伤口的愈合需要通过双态分子开关激活角质细胞迁移。该开关涉及从单个转录物中产生抗迁移微小RNA miR-198或前体迁移性卵泡抑素样1（FSTL1）蛋白；健康皮肤中miR-198的表达下调，有利于FSTL1的产生，增强角质形成细胞迁移并促进再上皮化。

本研究中，研究人员揭示了头颈鳞状细胞癌（HNSCC）中缺陷的分子开关。这种缺陷抑制了miR-198的表达，有利于持续的FSTL1翻译，通过DIAPH1和FSTL1的双重并行途径促使癌细胞的转移。DIAPH1是miR-198的一个靶标，通过与Arpin（Arp2/3复合物的竞争性抑制剂）的螯合增强了定向迁移能力。FSTL1阻断Wnt7a介导的细胞外信号调节激酶磷酸化的抑制，使得能够产生MMP9，可降解细胞外基质并促进细胞转移。

总之，该研究表明，FSTL1-DIAPH1基因对的预后意义使其成为治疗干预的有力靶标。

原始出处：

Gopinath M. Sundaram, Hisyam M. Ismail, et al., EGF hijacks miR-198/FSTL1 wound-healing switch and steers a two-pronged pathway toward metastasis. J Exp Med. 2017 Oct 2; 214(10): 2889–2900. doi: 10.1084/jem.20170354

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    2017-11-07 ms9608593228839890

    #DIA#

    0

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    2017-10-10 mashirong

    #上皮癌#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1638077, encodeId=3bf316380e7e0, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Nov 07 22:56:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539303, encodeId=4bff153930356, content=<a href='/topic/show?id=0e802002e45' target=_blank style='color:#2F92EE;'>#上皮癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20027, encryptionId=0e802002e45, topicName=上皮癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=866a13134648, createdName=mashirong, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608097, encodeId=a0e8160809e0b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619491, encodeId=3e47161949103, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251465, encodeId=151a2514656a, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Oct 09 07:22:35 CST 2017, time=2017-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251430, encodeId=d030251430fc, content=不错的文章.值得一读., beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Oct 09 00:06:08 CST 2017, time=2017-10-09, status=1, ipAttribution=)]
    2017-10-10 ms3994565386320060

    #Med#

    0

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    2017-10-10 docwu2019

    #有效治疗#

    0

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    2017-10-09 雅文博武

    学习了很多先进的医疗技术

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1638077, encodeId=3bf316380e7e0, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Nov 07 22:56:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539303, encodeId=4bff153930356, content=<a href='/topic/show?id=0e802002e45' target=_blank style='color:#2F92EE;'>#上皮癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20027, encryptionId=0e802002e45, topicName=上皮癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=866a13134648, createdName=mashirong, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608097, encodeId=a0e8160809e0b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619491, encodeId=3e47161949103, content=<a href='/topic/show?id=8dd46061824' target=_blank style='color:#2F92EE;'>#有效治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60618, encryptionId=8dd46061824, topicName=有效治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Tue Oct 10 02:56:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251465, encodeId=151a2514656a, content=学习了很多先进的医疗技术, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161027/IMG58114E1818EA51495.jpg, createdBy=4b2c1959822, createdName=雅文博武, createdTime=Mon Oct 09 07:22:35 CST 2017, time=2017-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251430, encodeId=d030251430fc, content=不错的文章.值得一读., beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Oct 09 00:06:08 CST 2017, time=2017-10-09, status=1, ipAttribution=)]
    2017-10-09 明天会更好！

    不错的文章.值得一读.

    0

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