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Semin Arthritis Rheu:银屑病关节炎的死亡率

2020-06-23 xiangting MedSci原创

年轻PsA患者的死亡风险升高。更好地控制合并症可以降低这种风险。

关于银屑病关节炎(PsA)死亡率的研究结果不一致。这项研究旨在:1)估算PsA患者死亡率随时间的变化趋势;2)与一般人群相比,评估PsA患者的特定原因死亡率;3)确定PsA死亡率的预测因子。

该研究是在多伦多银屑病关节炎诊所进行的,根据标准方案间隔6-12个月对患者进行前瞻性随访。参照安大略人口计算总体、不同年龄和性别的标准化死亡率(SMRs)。通过ICD9和ICD10编码记录死亡原因,并计算特定原因的SMRs。使用Cox回归模型确定PsA患者死亡率的预测因子。

对1490名患者随访了15062.8患者-年,225名患者(15%)被确认死亡(111名女性,114名男性)。总体SMR为0.92(95%CI:0.81-1.05),性别特异性SMRs为:女性1.08(95%CI:0.89-1.30),男性0.81(95%CI:0.66-0.97)。20-39岁、40-59岁、60-79岁和80岁以上的年龄特异性SMRs分别为3.36(95%CI:1.61-6.18)、0.97(95%CI:0.68-1.34)、0.88(95%CI:0.73-1.06)和0.86(95%CI:0.66-1.11)。死亡的主要原因包括恶性肿瘤(n=61; SMR=0.97,95%CI:0.72-1.28)、急性心肌梗塞(n=32; SMR=1.11,95%CI:0.74-1.58)和肺炎(n=14;SMR=2.46,95%CI:1.27-4.31)。被发现与死亡率升高相关的因素包括急性期反应物升高、存在合并症(如心脏病和癌症)以及受教育水平低。

年轻PsA患者的死亡风险升高。更好地控制合并症可以降低这种风险。

原始出处:

Ofir Elalouf. Mortality in psoriatic arthritis: Risk, causes of death, predictors for death. Semin Arthritis Rheu. August 2020.

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    2020-06-25 lmm397
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