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Lancet:藏在龙纹身中的恶性黑色素瘤

2015-12-26 MedSci MedSci原创

2015年10月,一名42岁白人男性患者因鼻唇沟和眉毛周围瘙痒同时伴有红斑和脱屑而就诊,其症状符合脂溢性皮炎的诊断。

2015年10月,一名42岁白人男性患者因鼻唇沟和眉毛周围瘙痒同时伴有红斑和脱屑而就诊,其症状符合脂溢性皮炎的诊断。

但是,在对患者进行全身皮肤检查时,医生发现,患者的皮肤存在很多色素痣,而且患者的整个背部、手臂以及胸部几乎纹满了龙的纹身。仔细检查发现,患者龙纹身的尾巴处存在一个发育不良痣(如图所示)。问诊后得知患者纹身时间为1年前,而此发育不良痣却至少存在了5年,纹身师有意在痣的周围进行了纹身。患者为II 型皮肤、金发、碧眼,曾在法国外籍兵团工作,长时间接受阳光暴晒。除儿童时期有过晒伤外,患者自述并无其他病史,也未接受任何药物治疗,也无皮肤病家族史。

手术完全切除发育不良痣,切除大小为1cm直径。组织学检查证实为浅表扩散性黑色素瘤,厚0-26 mm。根据美国癌症分期联合委员会(AJCC),肿瘤归为IA期。正常范围内进行额外的筛查。医生对患者进行了防晒医嘱,并根据AJCC建议对IA期黑色素瘤患者进行随访观察。患者并未出现疾病进展的迹象。



藏在纹身中的恶性黑色素瘤

(A)患者的背部照片,显示了藏在纹身中的病损部位(方框内)。(B)切除病损,直径为1cm,稍突出皮肤,边界及颜色不规则,从正常皮肤切入锐切除发育不良痣。(C)组织病理学检查显示为非溃疡性浅表扩散性黑色素瘤,厚0-26 mm,有丝分裂活性最小,并未出现血管或淋巴结浸润。

已有研究报道,许多皮肤病变(良性和恶性)与纹身有关。纹身所致的恶性转化机制尚未可知,所涉及的机制可能包括颜料的毒性作用和紫外线照射下颜料所引起的氧化应激反应以及慢性炎症反应,创伤诱发了现有病损的恶性变化,此外,纹身过程中创伤可致黑色素瘤细胞的扩散。本病例中,患者的不良色素痣并未受到纹身中创伤的影响。虽然纹身并没有看作是导致色素痣恶性化的危险因素,但是,医生应仔细检查纹身,因为纹身有可能会掩盖了恶性病变。

原始出处:

Georgi Tchernev, Melanoma in a Chinese dragon tattoo. Lancet, 23 December 2015.

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    2017-02-23 wmu姿

    如何让纹身更安全

    0

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    2016-05-10 howi
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    2016-07-03 sunylz
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