Tissue Cell：低氧张力调节小鼠胚胎干细胞的成骨分化

2018-06-23 MedSci MedSci原创

本研究检测了低氧压力对三维培养系统中胚胎干细胞（ESCs）成骨分化的影响。首次证实低氧条件下低氧相关蛋白低氧诱导因子-1α和血管内皮生长因子的表达升高。随后通过测量碱性磷酸酶活性，细胞内钙水平，基质矿化和成骨标志物Runt相关转录因子2和osterix的蛋白质水平来评估低氧ESCs与成骨或无骨生长因子培养基的成骨分化。随后通过测量碱性磷酸酶活性，细胞内钙水平，基质矿化和成骨标志物Runt相关转录因

本研究检测了低氧压力对三维培养系统中胚胎干细胞（ESCs）成骨分化的影响。首次证实低氧条件下低氧相关蛋白低氧诱导因子-1α和血管内皮生长因子的表达升高。

随后通过测量碱性磷酸酶活性，细胞内钙水平，基质矿化和成骨标志物Runt相关转录因子2和osterix的蛋白质水平来评估低氧ESCs与成骨或无骨生长因子培养基的成骨分化。

随后通过测量碱性磷酸酶活性，细胞内钙水平，基质矿化和成骨标志物Runt相关转录因子2和osterix的蛋白质水平来评估低氧ESC在成骨或无成骨生长因子培养基的成骨分化。结果发现，缺氧明显刺激ESC成骨活性，当细胞在成骨培养基中生长时，发挥最强的ESC成骨刺激作用。为了鉴定与缺氧诱导的ESC分化相关的差异表达的基因，我们对在常氧和缺氧条件下成骨培养基中的ESC进行了芯片分析。结果表明，氧张力的差异导致骨骼系统发育和骨形态发生蛋白，Wnt，Notch，促分裂原活化蛋白激酶和整联蛋白等信号通路中发挥作用的基因的差异表达。

综上所述，该研究结果揭示了低氧张力对胚胎干细胞成骨进程的影响，并提供深入了解低氧暴露后ESC分化的分子机制。

原始出处：

An SY, Heo JS. Low oxygen tension modulates the osteogenic differentiation of mouse embryonic stem cells. Tissue Cell. 2018 Jun;52:9-16. doi: 10.1016/j.tice.2018.03.007. Epub 2018 Mar 20.

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2019-03-28 维他命

#CEL#

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2019-04-26 HinsMax

#骨分化#

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2019-01-31 zhaojie88

#Tissue#

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2018-12-17 zhmscau

#张力#

69 0
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2019-02-06 zhaozhouchifen

#Cell#

69 0
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2018-06-25 ailian1202

#胚胎#

63 0
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2018-06-25 ms5880526374914242

#成骨分化#

68 0
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2018-06-25 zhaojie88

#胚胎干细胞#

79 0
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2018-06-25 zhaojie88

#成骨#

61 0

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Tissue Cell：低氧张力调节小鼠胚胎干细胞的成骨分化

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