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MedSci专访陈凯先院士:中医药送给世界的礼物--从屠呦呦教授获得诺奖说起

2015-11-09 MedSci MedSci原创

11月4日,上海科普大讲坛特邀我国著名药学家、中科院院士、上海市科协主席陈凯先院士,带领公众从青蒿素开始,走进中医药学的神奇世界,陈凯先院士跟我们分享《中医药送给世界的礼物》,并鼓励年轻科研工作者一定要发扬我国原创科技优势,加强中药和天然药物创新研究。 在此次分享会中,梅斯医学(MedSci)有幸采访到陈凯先院士。 MedSci:陈院士,您好,感谢您接受我们的采访,2015年10月,中国药

11月4日,上海科普大讲坛特邀我国著名药学家、中科院院士、上海市科协主席陈凯先院士,带领公众从青蒿素开始,走进中医药学的神奇世界,陈凯先院士跟我们分享《中医药送给世界的礼物》,并鼓励年轻科研工作者一定要发扬我国原创科技优势,加强中药和天然药物创新研究。

在此次分享会中,梅斯医学(MedSci)有幸采访到陈凯先院士。

MedSci:陈院士,您好,感谢您接受我们的采访,2015年10月,中国药学专家屠呦呦获得生理学或医学诺贝尔奖,使得“青蒿”,“青蒿素”倍受关注,那么以后我们如何从中药宝库中挖掘更多青蒿素这样的药物?当前存在哪些困难?

陈凯先院士:青蒿素在挖掘之前谁都不知道有这么好,在上世纪60年代中期,越南抗美战争不断升级,应越南领导人的要求,毛主席、周总理指示有关部门把解决热带地区部队遭受疟疾侵害、严重影响部队战斗力、军事行动等问题,作为一项紧急援外、备战重要任务立项。青蒿素就是在这一历史背景下,由60多家科研院所和企业共同组成的500多人参加的大协作科研队伍,在分工协同的组织模式下,科研人员四处去寻找,最后在医药宝库中挖掘除了青蒿素。所以我们首先一定要非常重视中医药的宝库。

二、关注重视当前亟待解决的重大问题

中医曾在麻醉,神经等领域创造过多个“世界第一”,如麻沸散是世界医学史上应用全身麻醉进行手术治疗的最早记载、用狂犬脑组织外敷伤口治疗狂犬咬伤开创了用免疫法治疗狂犬病的先河、首创用水银膏治疗皮肤病等,所以每个学科都有很多亟待要解决的问题,要善于抓住当前重点研究方向。

三、多学科交叉

中医药是我国具有原创优势的科技领域。在长期与疾病斗争的过程中,中医药形成了自己独特的理论体系和医疗模式,“治未病”、“辨证论治”、“经络和脏腑”等理论、治则和诊疗方体系,都具有我国独特的原创思维,蕴含着系统生物医学、生物化学等国际前沿的科学思想,所以我们要中西药学并举,运用多种科学交叉以及现代科技挖掘中医药学宝库,获得有重要国际影响的重大科技成果。

四、老药找新用途

在国外有一个策略,就是在已知的药源中去找新用途,因为老药的安全性和药效性都是已经完全掌握,这样就省去了很多的探索时间。比如埃博拉病毒爆发,全世界都在找治疗埃博拉病毒的药物,最后是来自美国得克萨斯生物医学研究所研究人员发现中草药提取成分汉防己碱来抑制埃博拉病毒传染,那么为什么不是我们中国人找到?既有客观原因也有主观原因,客观困难是我们没有埃博拉病毒,无法进行筛选研究,主观原因是我们自己研究工作做的不足,意识不足。

所以我们要需要建立一个非常完备的化合物宝库,瞄准国际重大问题,进行筛选,在已知的药源中去找相匹配的化合物进而研发药物。

五、坚持不懈

屠呦呦教授课题组搜集了808味可能抗疟的中药,在经历了190次失败后,终于在第191次低沸点试验中发现了抗疟效果为100%的青蒿提取物。在研究青蒿素化学结构中,团队又于1973年获得重大成果——首先发现了双氢青蒿素。屠呦呦教授亲自服用青蒿素,证实其安全性和有效性。所以,不要怕失败,要有坚持不懈的精神!

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    2015-11-11 fengyqf
  4. 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likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Mon Nov 09 16:51:00 CST 2015, time=2015-11-09, status=1, ipAttribution=)]
    2015-11-11 cathymary
  5. 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  6. 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  7. 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likeNumber=199, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Mon Nov 09 16:51:00 CST 2015, time=2015-11-09, status=1, ipAttribution=)]
    2015-11-10 荒唐的左

    祖国医学的博大精深!!!

    0

  8. 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  9. 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    2015-11-09 梦想天空

    0

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    2015-11-09 lixh1719

    怎么还说中医

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