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CGH:憩室炎患者罹患IBS风险增加

2014-01-24 佚名 不详

2013年12月刊发在Clin Gastroenterol Hepatol杂志上的一项回顾性研究结果显示,憩室炎患者进展为肠易激综合征(IBS)和功能性肠病的风险增加。 憩室病患者经常也会患有IBS,但是缺乏证明急性憩室炎与IBS,功能性肠病以及精神抑郁相关的纵向数据,为此,来自美国退伍军人事务部大洛杉矶医疗系统的Cohen博士及其同时在憩室炎患者中比较了IBS,功能

2013年12月刊发在Clin Gastroenterol Hepatol杂志上的一项回顾性研究结果显示,憩室炎患者进展为肠易激综合征(IBS)和功能性肠病的风险增加。【原文下载】

憩室病患者经常也会患有IBS,但是缺乏证明急性憩室炎与IBS,功能性肠病以及精神抑郁相关的纵向数据,为此,来自美国退伍军人事务部大洛杉矶医疗系统的Cohen博士及其同时在憩室炎患者中比较了IBS,功能性肠病以及情感性精神障碍的发病率,以研究憩室炎与IBS之间的关系。

研究共纳入了1,105例图表证实的憩室炎患者。所有病例均与同一天就诊的对照者相匹配,平均随访时间为6.3年,排除已经诊断IBS或功能性肠病的患者。主要终点是在索引憩室炎发作(对于病例而言)或入组(对于对照者而言)日期之后新诊断IBS.

研究者最终发现有24例患者在研究期间被新诊断为IBS:其中20例来自憩室炎病例,4例来自对照者。校正年龄、性别、种族、住院/门诊及合并症评分之后,病例与对照者相比的危险比(HR)为4.7(95% CI:1.6~14.0;P=0.006)。

对于憩室炎与新诊断IBS之间的关系,Cohen博士提出了若干种可能的解释。未来的研究应确定憩室炎后IBS的人口统计学和临床预测因素,并在前瞻性研究中评估其发病率,从而更好地确定这种关联是否为因果关系或只是相关而已。

原文出处:

Cohen E, Fuller G, Bolus R, Modi R, Vu M, Shahedi K, Shah R, Atia M, Kurzbard N, Sheen V, Agarwal N, Kaneshiro M, Yen L, Hodgkins P, Erder MH, Spiegel B.Increased risk for irritable bowel syndrome after acute diverticulitis.Clin Gastroenterol Hepatol. 2013 Dec;11(12):1614-9. doi: 10.1016/j.cgh.2013.03.007. Epub 2013 Mar 21.【原文下载】

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    2014-12-16 chendoc242
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    2014-01-26 yulin2006
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    2014-01-26 zutt

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