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Epigenetics:骨肉瘤衍生的细胞外囊泡影响间充质干细胞的转化

2019-03-26 不详 网络

细胞外囊泡(EV)是细胞间通讯的核心,在癌症进展和发展中起重要作用。骨肉瘤(OS)是一种侵袭性骨肿瘤,其特征在于存在恶性间充质细胞。目前对与OS发展相关的特定肿瘤驱动遗传改变知之甚少。已经假定成骨谱系的间充质干细胞(MSC)作为OS起源细胞的可能候选物,因此表明MSC和OS基质细胞可能是相关的细胞类型。因此,本研究旨在研究EV介导的MSCs和OS的细胞间串扰。在不同时间点用OS-EV处理MSC和前

细胞外囊泡(EV)是细胞间通讯的核心,在癌症进展和发展中起重要作用。骨肉瘤(OS)是一种侵袭性骨肿瘤,其特征在于存在恶性间充质细胞。目前对与OS发展相关的特定肿瘤驱动遗传改变知之甚少。已经假定成骨谱系的间充质干细胞(MSC)作为OS起源细胞的可能候选物,因此表明MSC和OS基质细胞可能是相关的细胞类型。因此,本研究旨在研究EV介导的MSCs和OS的细胞间串扰。

在不同时间点用OS-EV处理MSC和前成骨细胞,并通过LINE-1(长散布元件)和肿瘤抑制基因的甲基化分析评估OS-EV的表观遗传特征。此外,还评估了表面标志物和特定基因的表达。结果显示,OS-EV介导了MSC中的LINE-1低甲基化,而在成骨细胞前观察到相反的效应,表明MSCs但不是前成骨细胞对表观遗传转化敏感。因此,OS-EV通过调节表观遗传状态来调节MSC的转化,并且还影响与骨微环境重塑相关的基因的表达。

总体而言,该研究结果表明,表观遗传调控似乎是OS发展过程中MSCs转化的早期事件。阐明EV介导的沟通机制可能会为治疗开发带来新通路。

原始出处:

Mannerström B, Kornilov R, et al., Epigenetic alterations in mesenchymal stem cells by osteosarcoma-derived extracellular vesicles. Epigenetics. 2019 Mar 24:1-13. doi: 10.1080/15592294.2019.1585177.

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    2019-07-21 canlab
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createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=)]
  5. 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encodeId=4d4a1493585be, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599846, encodeId=275f15998463d, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=)]
    2019-11-24 huperzia
  6. 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  7. 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createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=)]
    2019-03-28 zhenjiu124
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encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Sat Nov 09 05:26:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878007, encodeId=9c9c18e80076b, content=<a href='/topic/show?id=5d80e943ef' target=_blank style='color:#2F92EE;'>#Genetics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7943, encryptionId=5d80e943ef, topicName=Genetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca89104, createdName=huperzia, createdTime=Sun Nov 24 00:26:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785742, encodeId=a29b1e85742fe, content=<a href='/topic/show?id=9e1a688138' target=_blank style='color:#2F92EE;'>#epigenetics#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6881, encryptionId=9e1a688138, topicName=epigenetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Sat Jul 13 11:26:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426373, encodeId=ec9214263e30f, content=<a href='/topic/show?id=032b948ec5' target=_blank style='color:#2F92EE;'>#IgE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9487, encryptionId=032b948ec5, topicName=IgE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cff4064659, createdName=zhenjiu124, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493585, encodeId=4d4a1493585be, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599846, encodeId=275f15998463d, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=)]
  9. 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objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6881, encryptionId=9e1a688138, topicName=epigenetics)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Sat Jul 13 11:26:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426373, encodeId=ec9214263e30f, content=<a href='/topic/show?id=032b948ec5' target=_blank style='color:#2F92EE;'>#IgE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9487, encryptionId=032b948ec5, topicName=IgE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0cff4064659, createdName=zhenjiu124, createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493585, 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createdTime=Thu Mar 28 06:26:00 CST 2019, time=2019-03-28, status=1, ipAttribution=)]
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