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Diabetes Care:血清25-羟维生素D、钙和甲状旁腺激素水平的遗传预测与2型糖尿病

2019-09-24 xing.T MedSci原创

由此可见,较高的S-25OHD水平与T2DM几率降低相关,但这种关联仅对维生素D合成途径中的SNP有效。S-Ca水平在T2DM发生发展中的可能作用需要进一步研究。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员进行了一项孟德尔随机研究,旨在探究遗传预测的血清25-羟基维生素D(S-25OHD)、钙(S-Ca)和甲状旁腺激素(S-PTH)水平与2型糖尿病(T2DM)之间的关系。

研究人员分别使用了与S-25OHD、S-Ca和S-PTH水平相关的七个、六个和五个单核苷酸多态性(SNP)作为工具变量。74124例T2DM受试者和824006例对照者T2DM的数据可用。主要分析采用逆方差加权方法,加权中位数和孟德尔随机(MR)-Egger方法作为辅助分析手段。

在主要分析中,研究人员发现遗传预测的S-25OHD而非S-Ca和S-PTH水平与T2DM相关。在基于所有七个SNP的分析中,S-25OHD水平每增加一个SD,T2DM的比值比(OR)为0.94(95%CI为0.88-0.99;P=0.029);而在基于与维生素D合成有关的基因或附近的三个SNP进行的分析中为0.90(95%CI为0.83-0.98; P=0.011)。加权中位数分析中仅基于维生素D合成SNP的相关性仍然存在,未检测到多效性(P=0.153)。在S-Ca分析中检测到多效性(P=0.013)。研究人员使用MR-Egger回归校正偏倚后,S-Ca水平每升高一个SD,T2DM的OR为1.41(95%CI为1.12–1.77;P=0.003)。

由此可见,较高的S-25OHD水平与T2DM几率降低相关,但这种关联仅对维生素D合成途径中的SNP有效。S-Ca水平在T2DM发生发展中的可能作用需要进一步研究。 

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    2019-09-24 misszhang

    谢谢MedSci提供最新的资讯

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