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Eur J Heart Fail:肺癌、结肠癌或胰腺癌患者室性心动过速、室性早搏和死亡率的关系

2020-11-25 MedSci原创 MedSci原创

结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。

许多癌症患者死于血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。

近日,心血管领域权威杂志European Journal of Heart Failure上发表了一篇研究文章,在2005年至2010年之间,研究人员前瞻性地招募了120名未筛选的肺癌、结肠癌胰腺癌的患者,他们有以下三种诊断之一:大肠癌(n=33)、胰腺癌(n=54)或非小细胞肺癌(n=33),且全部没有明显的心血管疾病。研究人员将他们与年龄和性别分布相似的43名健康对照者进行了比较。每位参与者进行24小时心电图记录,并随访癌症患者长达12.5年的生存时间(中位数为21个月)。

96名(80%)癌症患者在随访期间死亡(5年生存期:27%[95%CI为19-35%])。与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高(8% vs. 0%,p=0.021)。与对照组相比,癌症患者在24小时内的室性早搏(PVC)数量没有增加(中位数为4 vs. 9,p=0.2)。在多变量分析中,NSVT(HR为2.44,p=0.047)和PVCs(每100的HR为1.021,p=0.047)都是死亡率的重要预测指标,而与其他单变量死亡率预测指标无关,包括肿瘤分期、癌症类型、钾浓度、既往手术、心脏毒性化疗和血红蛋白。在大肠癌和胰腺癌患者中,PVCs≥50/24小时可预测死亡率(HR为2.30,p=0.0024),并且分别在18%和26%的患者中被发现。

由此可见,结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。

原始出处:

Markus S Anker.et al.Ventricular tachycardia, premature ventricular contractions, and mortality in unselected patients with lung, colon, or pancreatic cancer: a prospective study.European journal of heart failure.2019.https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2059

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    2020-11-27 咻凡

    许多癌症患者死于心血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。

    0

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    2020-11-26 zhaojie88
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  4. [GetPortalCommentsPageByObjectIdResponse(id=902864, encodeId=26e9902864a9, content=许多癌症患者死于心血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Nov 27 16:23:35 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357616, encodeId=3e53135e6164f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407864, encodeId=c66f140e864da, content=<a href='/topic/show?id=75f34622831' target=_blank style='color:#2F92EE;'>#室性心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46228, encryptionId=75f34622831, topicName=室性心动过速)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19932732764, createdName=kalseyzl, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424072, encodeId=be9114240e26a, content=<a href='/topic/show?id=607146230d1' target=_blank style='color:#2F92EE;'>#室性早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46230, encryptionId=607146230d1, topicName=室性早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db03894351, createdName=hunizi006, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471128, encodeId=fdb114e1128cf, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521424, encodeId=06ee152142430, content=<a href='/topic/show?id=eee459319c0' target=_blank style='color:#2F92EE;'>#早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59319, encryptionId=eee459319c0, topicName=早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1f611339865, createdName=bioon7, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563380, encodeId=6e34156338050, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902091, encodeId=969f9020913b, content=与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 25 10:45:19 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902062, encodeId=1256902062f8, content=结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:22:58 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
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  6. [GetPortalCommentsPageByObjectIdResponse(id=902864, encodeId=26e9902864a9, content=许多癌症患者死于心血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Nov 27 16:23:35 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357616, encodeId=3e53135e6164f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407864, encodeId=c66f140e864da, content=<a href='/topic/show?id=75f34622831' target=_blank style='color:#2F92EE;'>#室性心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46228, encryptionId=75f34622831, topicName=室性心动过速)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19932732764, createdName=kalseyzl, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424072, encodeId=be9114240e26a, content=<a href='/topic/show?id=607146230d1' target=_blank style='color:#2F92EE;'>#室性早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46230, encryptionId=607146230d1, topicName=室性早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db03894351, createdName=hunizi006, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471128, encodeId=fdb114e1128cf, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521424, encodeId=06ee152142430, content=<a href='/topic/show?id=eee459319c0' target=_blank style='color:#2F92EE;'>#早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59319, encryptionId=eee459319c0, topicName=早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1f611339865, createdName=bioon7, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563380, encodeId=6e34156338050, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902091, encodeId=969f9020913b, content=与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 25 10:45:19 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902062, encodeId=1256902062f8, content=结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:22:58 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-26 bioon7
  7. [GetPortalCommentsPageByObjectIdResponse(id=902864, encodeId=26e9902864a9, content=许多癌症患者死于心血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Nov 27 16:23:35 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357616, encodeId=3e53135e6164f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407864, encodeId=c66f140e864da, content=<a href='/topic/show?id=75f34622831' target=_blank style='color:#2F92EE;'>#室性心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46228, encryptionId=75f34622831, topicName=室性心动过速)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19932732764, createdName=kalseyzl, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424072, encodeId=be9114240e26a, content=<a href='/topic/show?id=607146230d1' target=_blank style='color:#2F92EE;'>#室性早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46230, encryptionId=607146230d1, topicName=室性早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db03894351, createdName=hunizi006, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471128, encodeId=fdb114e1128cf, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521424, encodeId=06ee152142430, content=<a href='/topic/show?id=eee459319c0' target=_blank style='color:#2F92EE;'>#早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59319, encryptionId=eee459319c0, topicName=早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1f611339865, createdName=bioon7, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563380, encodeId=6e34156338050, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902091, encodeId=969f9020913b, content=与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 25 10:45:19 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902062, encodeId=1256902062f8, content=结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:22:58 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-26 slcumt
  8. [GetPortalCommentsPageByObjectIdResponse(id=902864, encodeId=26e9902864a9, content=许多癌症患者死于心血管疾病和猝死,但有关室性心律失常患病率和预后意义的数据尚未明确。, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b58d5402080, createdName=咻凡, createdTime=Fri Nov 27 16:23:35 CST 2020, time=2020-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357616, encodeId=3e53135e6164f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407864, encodeId=c66f140e864da, content=<a href='/topic/show?id=75f34622831' target=_blank style='color:#2F92EE;'>#室性心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46228, encryptionId=75f34622831, topicName=室性心动过速)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19932732764, createdName=kalseyzl, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1424072, encodeId=be9114240e26a, content=<a href='/topic/show?id=607146230d1' target=_blank style='color:#2F92EE;'>#室性早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46230, encryptionId=607146230d1, topicName=室性早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8db03894351, createdName=hunizi006, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471128, encodeId=fdb114e1128cf, content=<a href='/topic/show?id=f06c5090466' target=_blank style='color:#2F92EE;'>#心动过速#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50904, encryptionId=f06c5090466, topicName=心动过速)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35817104001, createdName=fengyi814, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1521424, encodeId=06ee152142430, content=<a href='/topic/show?id=eee459319c0' target=_blank style='color:#2F92EE;'>#早搏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59319, encryptionId=eee459319c0, topicName=早搏)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1f611339865, createdName=bioon7, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563380, encodeId=6e34156338050, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Nov 26 23:10:13 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902091, encodeId=969f9020913b, content=与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Wed Nov 25 10:45:19 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902062, encodeId=1256902062f8, content=结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:22:58 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-25 Jessica

    与对照组相比,癌症患者的非持续性室性心动过速(NSVT)频率更高。

    0

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    2020-11-25 Sunny orchard

    结直肠癌、胰腺癌和非小细胞肺癌患者,非持续性室性心动过速更为常见,并且与PVC一起可预测长期死亡率。这提高了心血管死亡率成为某些癌症未来治疗干预目标的可能性。

    0

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调控细胞命运的多条信号通路对于个体正常发育和自身稳态是不可或缺的。Wnt信号通路在干细胞维持、胚胎发育和肿瘤发生发展过程中起着至关重要的作用。该通路关键因子的活性受翻译后修饰(如磷酸化和泛素化)的调控

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