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CD44作为筛选下咽癌肿瘤干细胞分子标志物的价值

2014-02-07 佚名 不详

近日,上海交通大学医学院附属新华医院耳鼻咽喉头颈外科,上海交通大学医学院耳科学研究所研究人员发表论文,旨在探讨CD44作为筛选下咽癌肿瘤干细胞分子标记物的价值。研究指出,下咽癌肿瘤中CD44+细胞比CD44-细胞具有更强的体外增殖能力和体内致瘤能力,提示肿瘤干细胞可能存在于CD44+肿瘤细胞内,CD44可作为筛选下咽癌肿瘤干细胞的一个重要分子标记物。该文发表在2013年第05期《中国耳鼻咽喉颅底外

近日,上海交通大学医学院附属新华医院耳鼻咽喉头颈外科,上海交通大学医学院耳科学研究所研究人员发表论文,旨在探讨CD44作为筛选下咽癌肿瘤干细胞分子标记物的价值。研究指出,下咽癌肿瘤中CD44+细胞比CD44-细胞具有更强的体外增殖能力和体内致瘤能力,提示肿瘤干细胞可能存在于CD44+肿瘤细胞内,CD44可作为筛选下咽癌肿瘤干细胞的一个重要分子标记物。该文发表在2013年第05期《中国耳鼻咽喉颅底外科杂志》上。

应用流式细胞仪检测下咽癌FADU细胞系中CD44的表达;采用免疫磁珠分选技术(MACS)分选CD44+细胞,并用流式细胞仪检测其纯度;运用四甲基偶氮唑蓝(MTT)比色法检测CD44+、CD44-细胞的体外增殖能力,将相同数量级(1×106、1×105)的CD44+、CD44-细胞分别注射于雄性非肥胖糖尿病型/重症联合免疫缺陷(non-obese diabetic/severe combined immunodefi ciency,NOD/SCID)小鼠皮下,观察其体内致瘤能力的差异。

下咽癌FADU细胞系中CD44+细胞占(21.1±1.56)%,免疫磁珠分选后的CD44+细胞纯度达(99.4±0.29)%。体外增殖能力研究显示CD44+细胞增殖速度明显快于CD44-细胞。NOD/SCID鼠体内致瘤实验结果显示:1×105CD44+细胞致瘤率为12.5%(1/8),1×105 CD4 4-细胞致瘤率为0(0/8);1×106 CD44+细胞致瘤率为100%(8/8),1×106 CD4 4-细胞致瘤率为5 0%(4/8);相同数量级的CD44+与CD44-两组细胞致瘤率差异具有统计学意义(P<0.05)。此外,CD44+细胞组比CD44-细胞组更早成瘤,潜伏期明显缩短。CD44+细胞组所致肿瘤体积平均为(2017.81±538.50)mm3,而CD44-细胞组所致肿瘤体积平均为(1153.25±503.18)mm3,两组差异具有统计学意义(t=2.67,P<0.05)。

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    2014-04-16 qidongfanjian
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    2014-02-09 fusion
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近日,南开大学生命科学学院陈佺教授课题组在结肠癌肿瘤研究方面取得重大进展,研究成果被临床肿瘤期刊Clinical Cancer Research杂志接收。生命科学学院陈佺教授为通讯作者,博士生饶冠华为第一作者,本研究由南开大学和中国科学院动物研究所合作完成。

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