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Hypertension:胎盘生长因子筛查无症状女性先兆子痫的性能

2019-09-16 xing.T MedSci原创

由此可见,PlGF是预测先兆子痫的有用筛选工具。尽管如此,应谨慎判断其效用,并且有必要进行随机对照试验以探讨检查PlGF是否能改善无症状女性的围产期结局。

先兆子痫是一种全身性综合征,似乎起源于胎盘,并且与母体循环中血管生成因子之间的不平衡有关。经过充分研究和广泛使用的因素之一是胎盘生长因子(PlGF),其水平下降的女性注定会发展为先兆子痫。已知PlGF的下降先于先兆子痫体征和症状的发展,因此证明其是预测先兆子痫有用的筛选工具。然而,评估其临床有用性方面的文献结果变化很大。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员进行了一项荟萃分析,以探究PlGF在无症状女性中的预测准确性。研究人员分析了40项研究,3189名先兆子痫患者和89498名对照者。

该分析的总预测比值比为9(6-13)。评估各种PlGF阈值的亚组分析表明,PlGF水平在80和120 pg/mL之间的预测值最高,预测比值比高达25(7-88),灵敏度为0.78(95%CI为0.67-0.86),特异性为0.88(95%CI为0.75-0.95),阳性似然比为6.3(95%CI为2.7-14.7),阴性似然比为0.26(95%CI为0.16-0.42)。此外,在妊娠14周后进行检查,其准确性更高(OR为10[7-15]),并且可预测早发型先兆子痫(OR为18 [9-37])。

由此可见,PlGF是预测先兆子痫的有用筛选工具。尽管如此,应谨慎判断其效用,并且有必要进行随机对照试验以探讨检查PlGF是否能改善无症状女性的围产期结局。 

原始出处:

A Systematic Review and Meta-Analysis.Hypertension.2019.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13360

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    2019-09-27 feather89
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Lancet:胎盘生长因子检测用于先兆子痫的确诊

研究认为PLGF检测可有效缩短先兆子痫临床确认时间

Circulation:胎盘生长因子能否预测女性妊娠后心血管风险?

妊娠期间血管生成胎盘生长因子(PlGF)浓度上升,在妊娠中期结束时达到峰值。妊娠期间低PlGF浓度与妊娠并发症相关,并具有公认的晚年心血管风险。Circulation发表的一项研究假设低PlGF浓度,特别是在妊娠中期,不仅可识别具有妊娠并发症风险的女性子集,而且还可诊断妊娠后心血管危险因素负担较大的女性,无论妊娠结局如何。

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