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Neurology:帕金森病患者轻度行为障碍与认知和脑萎缩有关

2019-07-22 xing.T MedSci原创

由此可见,PD-MBI组中所有领域的认知功能受损和颞区萎缩与PD的后皮质回路缺陷一致,这与痴呆进展速度更快有关。这些初步结果表明,MBI可能是PD患者认知衰退和痴呆事件的早期重要标志。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估帕金森病(PD)患者轻度行为障碍(MBI)与认知缺陷和灰质变化模式之间的关系。

研究人员对60例无痴呆PD患者和29例健康对照者进行认知神经心理学评估和结构MRI扫描,并使用MBI检查表(MBI-C)评估MBI,MBI检查表是一种评定量表,旨在根据MBI标准引发紧急神经精神症状。研究人员将PD患者分为2组:1组具有高MBI-C评分组(PD-MBI),另一组具有低MBI-C评分组(PD-noMBI)。

在60例PD患者中,20例分为PD-MBI组(33.33%)。在健康对照组中,没有参与者达到MBI临界点阈值。与健康对照组和PD-noMBI组相比,PD-MBI组蒙特利尔认知评估和5个领域的z评分以及整体评分均显著较低。此外,除语言和整体认知外的所有认知领域与所有PD患者的MBI-C总分均呈负相关。对于皮质结构,与PD-noMBI组相比,PD-MBI组显示中颞皮质变薄和体积减小,并且该区域的体积减小与MBI-C总分呈负相关。

由此可见,PD-MBI组中所有领域的认知功能受损和颞区萎缩与PD的后皮质回路缺陷一致,这与痴呆进展速度更快有关。这些初步结果表明,MBI可能是PD患者认知衰退和痴呆事件的早期重要标志。 

原始出处:

Eun Jin Yoon.et al.Mild behavioral impairment is linked to worse cognition and brain atrophy in Parkinson disease.Neurology.2019.https://doi.org/10.1212/WNL.0000000000007968

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    2020-01-10 yinhl1978
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    2020-01-18 chendoc252
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