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双抗体鸡尾酒疗法REGN-COV2:再生元启动针对新冠病毒COVID-19的首项临床研究

2020-06-11 MedSci原创 MedSci原创

REGN-COV2结合了两种抗体,它们非竞争性地与SARS-CoV-2病毒刺突蛋白的受体结合域结合,以降低突变病毒的逃逸。

再生元(Regeneron Pharmaceuticals)公司宣布,已开始对其双抗体混合物REGN-COV2用于预防和治疗新型冠状病毒COVID-19,开展首项临床研究。

See the source image

该公司指出,REGN-COV2结合了两种抗体REGN10933和REGN10987,它们非竞争性地与SARS-CoV-2病毒刺突蛋白的受体结合域(RBD)结合,以降低突变病毒的逃逸。

根据Regeneron的说法,REGN-COV2临床计划将由四个独立的研究人群组成,包括住院和非住院的新冠COVID-19感染患者、处​​于高风险暴露人群中的未感染人群和与COVID-19患者密切接触的未感染人群。

Regeneron的首席科学官George Yancopoulos表示,REGN-COV2具有“预防和治疗感染COVID-19的潜能,也有可能阻止病毒的逃逸”。

原始出处:

https://www.firstwordpharma.com/node/1731740?tsid=4

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    2020-12-22 黑布林

    积极配合

    0

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    2020-06-13 qblt
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    2020-06-11 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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根据世界卫生组织(WHO)错误发布的草稿文件,吉利德的remdesivir未能改善重症新型冠状病毒COVID-19感染患者的病情,也不能减轻该病毒在血液中的浓度。

OCC 2020丨羟氯喹在免疫性疾病相关性肺动脉高压中的作用及在新冠肺炎中的价值

5月29日,第十四届东方心脏病学会议(OCC2020)上,李梦涛教授就“SLE-PAH基础病的治疗选择”和“羟氯喹在免疫性疾病相关性肺动脉高压中的作用及在新冠肺炎中的价值”的主题与各位专家进行了分享.

NEJM:疟疾药物羟氯喹在另一项新冠病毒研究中没有显示任何益处

新闻来源指出,接受羟氯喹治疗的患者通常比其他患者病重。

Lancet oncol:武汉感染新冠病毒的癌症患者的临床特征及与严重程度的危险因素

COVID-19已经在全球蔓延。据报道,癌症患者对新冠病毒有流行病学敏感性。本研究目的是系统地描述癌症患者罹患COVID-19后的临床特征,并明确决定癌症患者感染COVID-19后严重程度的危险因素。

IL-6试验令人失望后,诺华将测试IL-1单抗canakinumab用于抵抗新冠COVID-19的细胞因子风暴

新型冠状病毒COVID-19患者体内的炎症因子IL-1β水平显着升高。

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