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Int Forum Allergy Rhinol:冷冻疗法治疗慢性鼻炎的效果怎样?

2021-08-20 AlexYang MedSci原创

通过翼管神经切除术和鼻后神经切除术阻断副交感神经支配鼻腔粘膜能够减少鼻腔引流。尽管疗效已被证明,这些手术技术是侵入性的,需要全身麻醉和专门的器械,并可能与潜在的毁灭性并发症相关。

通过翼管神经切除术和鼻后神经切除术阻断副交感神经支配鼻腔粘膜能够减少鼻腔引流。尽管疗效已被证明,这些手术技术是侵入性的,需要全身麻醉和专门的器械,并可能与潜在的毁灭性并发症相关。

近期,有研究人员测试了在减轻慢性鼻炎的症状方面,冷冻疗法是否优于假手术

研究为前瞻性、多中心、1:1随机、sham对照、患者盲法试验。预先设计决定的样本量为每组61名参与者。研究人员招募了那些有中度/重度慢性鼻炎症状的成人,将他们作为局部麻醉下冷冻治疗的候选者。要求参与者的反射性总鼻症状评分(rTNSSs)最低为4分,鼻漏评分为2分,鼻塞评分为1分。随访时间分别为术后30天和90天。患者报告的结果测量包括rTNSS、标准化鼻结膜炎生活质量问卷[RQLQ(S)]和鼻塞症状评估问卷(NOSE)。同时记录了不良事件。主要终点是比较治疗组和sham组90天反应者的百分比。反应者定义为rTNSS相对于基线降低30%或更多的参与者

研究包括了美国12个调查中心招募的133名参与者。主要终点分析包括127名参与者(64名手术参与者,63名假手术参与者)的90天结果。在90天随访中,治疗组有73.4%(64例中有47例)有反应,而假手术组有36.5%(63例中有23例)有反应(p<0.001)。90天随访时,手术组的rTNSS、RQLQ(S)和NOSE评分比假手术组有更大的改善(p<0.001)。同时,研究报告了一个严重的手术过程相关的不良事件,即焦虑/恐慌发作。

随访期间的总rTNSSs得分情况

综上所述,冷冻治疗在改善慢性鼻炎症状和患者生活质量方面要优于假手术

原始出处:

Anthony G Del Signore , Joshua B Greene , Joseph L Russell et al. Cryotherapy for treatment of chronic rhinitis: 3-month outcomes of a randomized, sham-controlled trial. Int Forum Allergy Rhinol. Aug 2021

 

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    2021-08-21 仁医06
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    2021-08-20 daanbang

    thank you

    0

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    2021-08-20 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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