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Thorax:恶性胸膜间皮瘤早期专科姑息治疗对生活质量的影响

2019-01-22 xiangting MedSci原创

对于在提供SPC的中心进行治疗的患者,MPM诊断后不久常规转诊至SPC并没有作用。

恶性胸膜间皮瘤(MPM)的症状负担高,存活率低。来自其他癌症类型的证据表明,早期专科姑息治疗(SPC)与肿瘤服务相结合可以有一些健康相关的生活质量(HRQoL)获益,但证据的确定性很低。

这是一项多中心、随机、平行组对照试验,比较了英国19家医院和西澳大利亚一家大型医院的早期转诊SPC vs标准治疗。参与者为新诊断的MPM患者;另外招募了主要护理人员。治疗:在分配后3周内进行SPC审查和整个研究中每4周进行一次检查。在基线时和每4周使用欧洲癌症研究和治疗组织(EORTC)生活质量问卷核心30评估HRQoL。主要结局:随机化后12周EORTC C30整体健康状况的改变。

2014年4月至2016年10月期间,174名参与者被随机分组。12周时组间HRQoL评分无显著差异(平均差异1.8(95%CI -4.9至8.5; p=0.59))。24周时HRQoL没有差异(平均差异-2.0(95%CI -8.6至4.6; p=0.54))。12周或24周时抑郁/焦虑评分没有差异。在护理人员中,尽管一直倾向于治疗,12周或24周的HRQoL或情绪没有差异,其中干预组较优。

对于在提供SPC的中心进行治疗的患者,MPM诊断后不久常规转诊至SPC并没有作用。

原始出处:

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    2019-12-29 lifestar
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    2019-01-23 医者仁心5538

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1666274, encodeId=537216662e4e6, content=<a href='/topic/show?id=bbaf8420118' target=_blank style='color:#2F92EE;'>#胸膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84201, encryptionId=bbaf8420118, topicName=胸膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbc026056217, createdName=lifestar, createdTime=Sun Dec 29 14:40:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715380, encodeId=75971e153805d, content=<a href='/topic/show?id=235220e0106' target=_blank style='color:#2F92EE;'>#专科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20701, encryptionId=235220e0106, topicName=专科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=894231925290, createdName=12498ebem29暂无昵称, createdTime=Thu Aug 29 23:40:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579806, encodeId=c2d915e98069f, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Thu Jan 24 09:40:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626658, encodeId=f0911626658b9, content=<a href='/topic/show?id=2d91449540c' target=_blank style='color:#2F92EE;'>#姑息#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44954, encryptionId=2d91449540c, topicName=姑息)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adea21051784, createdName=经常头晕, createdTime=Thu Jan 24 09:40:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359070, encodeId=6bc73590e094, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Jan 23 23:00:29 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359019, encodeId=3f7c359019fe, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 23 19:41:20 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358946, encodeId=20bf3589465c, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Jan 22 20:30:04 CST 2019, time=2019-01-22, status=1, ipAttribution=)]
    2019-01-23 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1666274, encodeId=537216662e4e6, content=<a href='/topic/show?id=bbaf8420118' target=_blank style='color:#2F92EE;'>#胸膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84201, encryptionId=bbaf8420118, topicName=胸膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fbc026056217, createdName=lifestar, createdTime=Sun Dec 29 14:40:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715380, encodeId=75971e153805d, content=<a href='/topic/show?id=235220e0106' target=_blank style='color:#2F92EE;'>#专科#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20701, encryptionId=235220e0106, topicName=专科)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=894231925290, createdName=12498ebem29暂无昵称, createdTime=Thu Aug 29 23:40:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579806, encodeId=c2d915e98069f, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Thu Jan 24 09:40:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626658, encodeId=f0911626658b9, content=<a href='/topic/show?id=2d91449540c' target=_blank style='color:#2F92EE;'>#姑息#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44954, encryptionId=2d91449540c, topicName=姑息)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=adea21051784, createdName=经常头晕, createdTime=Thu Jan 24 09:40:00 CST 2019, time=2019-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359070, encodeId=6bc73590e094, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Jan 23 23:00:29 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359019, encodeId=3f7c359019fe, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 23 19:41:20 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358946, encodeId=20bf3589465c, content=学习了,涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Tue Jan 22 20:30:04 CST 2019, time=2019-01-22, status=1, ipAttribution=)]
    2019-01-22 王秀

    学习了,涨知识了!

    0

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