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JAMA:异麦芽糖苷铁与羧甲基麦芽糖铁对缺铁性贫血患者低磷酸盐血症的影响

2020-02-14 不详 网络

目前尚未清楚使用异麦芽糖苷铁(现在称为三去甲麦芽糖铁)与羧基麦芽糖铁替代铁后发生低磷血症的风险。在2项随机试验中,研究人员纳入了245名(试验A:n = 123,试验B:n = 122)对口服铁不耐受或无反应的铁缺乏性贫血患者进行了探究。结果显示,异麦芽糖苷铁VS. 羧基麦芽糖铁,引起的低磷血症发生率在35天内分别为7.9% VS.75.0%(试验A)和8.1%VS. 73.7%(试验B);两组试

目前尚未清楚使用异麦芽糖苷铁(现在称为三去甲麦芽糖铁)与羧基麦芽糖铁替代铁后发生低磷血症的风险。


在2项随机试验中,研究人员纳入了245名(试验A:n = 123,试验B:n = 122)对口服铁不耐受或无反应的铁缺乏性贫血患者进行了探究。

结果显示,异麦芽糖苷铁VS. 羧基麦芽糖铁,引起的低磷血症发生率在35天内分别为7.9% VS.75.0%(试验A)和8.1%VS. 73.7%(试验B);两组试验差异均具有统计学意义。

综上所述,该研究结果表明,与羧基麦芽糖铁相比,异麦芽糖苷铁降低了低磷血症的发生率,但是需要进一步的研究来确定这些发现的临床重要性。

原始出处:

Myles Wolf, Janet Rubin, et al., Effects of Iron Isomaltoside vs Ferric Carboxymaltose on Hypophosphatemia in Iron-Deficiency Anemia Two Randomized Clinical Trials. JAMA. 2020;323(5):432-443. doi:10.1001/jama.2019.22450

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    2020-02-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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