JAMA：病毒变异后疫苗还有用吗？SARS-CoV-2感染和接种后的中和抗体检测

2021-03-20 MedSci原创 MedSci原创

SARS-CoV-2变异引起了人们对中和抗体反应广度的关注。

血清中和抗体在SARS-CoV-2感染和疫苗接种后迅速出现并维持数月。SARS-CoV-2变异引起了人们对中和抗体反应广度的关注。有研究者比较了感染和接种个体中和抗体对4种变异的反应，以确定棘突蛋白内的突变与病毒中和的关系。研究结果近日发表在JAMA杂志上。

血清样本取自3组个体。在埃默里大学，有SARS-CoV-2感染（聚合酶链反应证实）的住院成人在症状出现后5至19天（2020年7月）被纳入研究。感染恢复期个体(经聚合酶链反应或抗原检测证实)在症状出现后32至94天(2020年3月至8月)被纳入研究。在第二次给药后14天（100μg组群）从mRNA-1273 1期临床试验的个体中提取的未鉴定血清样本来自美国国立卫生研究院。

Pixabay.com

检测了四种变异，分别代表原始的SARS-CoV-2毒株和棘突蛋白突变的新变异。第一个变种nCoV/USA\uwa1/2020（A.1谱系）与武汉原株和mRNA-1273疫苗中使用的尖峰非常相似，是从传染性SARS-CoV-2克隆中繁殖的。

第二个变种，EHC-083E（B.1谱系），在峰值内含有D614G突变，是研究时的主要循环菌株，并于2020年3月从乔治亚州亚特兰大的一名患者的残留鼻咽拭子中分离出来（SARS-CoV-2/human/USA/GA-EHC-083E/2020）。

第三个变种B.1.1.7（SARS-CoV-2/human/USA/CA\U CDC\U 5574/2020）最初是在英国发现的，由于传染性增加而引起关注。它包含几个尖峰突变，并于2020年12月从加利福尼亚州圣地亚哥的一名患者的鼻咽拭子中分离出来。

第四个变种，N501Y SARS-CoV-2病毒，在多个新出现的变种（包括本研究中的B.1.1.7变种）中存在的尖峰关键受体结合域中含有突变，如前所述，是从一个感染性克隆中产生的。这种病毒在自然界中没有发现。

20例急性感染COVID-19的患者提供了血清样本（平均年龄56.6岁，50%为男性）。A.1变体的FRNT₅₀ GMT为186（95%CI，90-383）；B.1为110（95%CI，57-209）；B.1.1.7为116（95%CI，62-215）；N501Y为141（95%CI，74-269）。两种变异的FRNT₅₀ GMT比较无统计学意义。

20名康复者提供了血清样本（平均年龄45岁；55%为男性）。A.1变体的FRNT₅₀ GMT为168（95%CI，113-249）；B.1为91（95%CI，60-138）；B.1.1.7为145（95%CI，96-220）；N501Y为145（95%CI，76-172）。变异的FRNT₅₀ GMT的比较没有统计学意义。

14个mRNA-1273接种个体的血清样本可用（年龄范围，18-55岁；43%为男性）。A.1变种的FRNT₅₀ GMT为1709（95%CI，1412-2069）；B.1为804（95%CI，632-1023）；B.1.1.7为965（95%CI，695-1341）；N501Y为994（95%CI，777-1272）。B.1、B.1.1.7和N501Y变体的FRNT₅₀ GMT比较无统计学意义。B.1（P<0.001）、B.1.1.7（P=0.02）和N501Y（P=0.02）变异的FRNT₅₀ GMT在统计学上显著低于A.1变异。

SARS-CoV-2变异的中和抗体应答

该研究发现，感染和疫苗诱导抗体对4种SARS-CoV-2变种(包括B.1、B.1.1.7和N501Y)具有中和活性。因为中和性研究衡量的是抗体阻止病毒感染的能力，这些结果表明感染和疫苗诱导的免疫可能对B.1.1.7变异保留。随着其他变异的出现，感染和接种疫苗后的中和抗体反应应被监测。

参考文献：Edara VV, Hudson WH, Xie X, Ahmed R, Suthar MS. Neutralizing Antibodies Against SARS-CoV-2 Variants After Infection and Vaccination. JAMA. Published online March 19, 2021. doi:10.1001/jama.2021.4388

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2021-06-11 hukaixun

#SARS-CoV#

54 0
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2021-03-22 marongnuan

#体检#

59 0
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2021-03-22 小刀医生

#SARS#

0 0
[GetPortalCommentsPageByObjectIdResponse(id=1937998, encodeId=fbf6193e99826, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 11 22:36:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305240, encodeId=221d130524091, content=<a href='/topic/show?id=ba392659e58' target=_blank style='color:#2F92EE;'>#体检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26597, encryptionId=ba392659e58, topicName=体检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321264, encodeId=5922132126437, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342796, encodeId=2f501342e963f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491056, encodeId=06231491056a1, content=<a href='/topic/show?id=a63ce0908b3' target=_blank style='color:#2F92EE;'>#病毒变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70908, encryptionId=a63ce0908b3, topicName=病毒变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a528868216, createdName=zhyy91, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535801, encodeId=ebdb15358011a, content=<a href='/topic/show?id=0e8a551866c' target=_blank style='color:#2F92EE;'>#抗体检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55186, encryptionId=0e8a551866c, topicName=抗体检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682812619358, createdName=tongyongming, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949850, encodeId=6c3f949850fa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/1f3a8e64c4dc4559af4d21a37afef10a/3632634089c24e5c807a83138e2529ce.jpg, createdBy=c3d35445259, createdName=悠悠sunny, createdTime=Sun Mar 21 08:43:38 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036534, encodeId=3ba810365346d, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 20 16:36:47 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949713, encodeId=a0ad949e1364, content=想看个原文真是费尽心血, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210320/b37509b5a7b2414586f8a02a8c0bbac5/4a4423496ce64105b7466d719b7718d4.jpg, createdBy=27b85459409, createdName=ms2000000903172319, createdTime=Sat Mar 20 14:52:24 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
2021-03-22 12498dabm77暂无昵称

#变异#

55 0
[GetPortalCommentsPageByObjectIdResponse(id=1937998, encodeId=fbf6193e99826, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 11 22:36:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305240, encodeId=221d130524091, content=<a href='/topic/show?id=ba392659e58' target=_blank style='color:#2F92EE;'>#体检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26597, encryptionId=ba392659e58, topicName=体检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321264, encodeId=5922132126437, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342796, encodeId=2f501342e963f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491056, encodeId=06231491056a1, content=<a href='/topic/show?id=a63ce0908b3' target=_blank style='color:#2F92EE;'>#病毒变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70908, encryptionId=a63ce0908b3, topicName=病毒变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a528868216, createdName=zhyy91, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535801, encodeId=ebdb15358011a, content=<a href='/topic/show?id=0e8a551866c' target=_blank style='color:#2F92EE;'>#抗体检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55186, encryptionId=0e8a551866c, topicName=抗体检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682812619358, createdName=tongyongming, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949850, encodeId=6c3f949850fa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/1f3a8e64c4dc4559af4d21a37afef10a/3632634089c24e5c807a83138e2529ce.jpg, createdBy=c3d35445259, createdName=悠悠sunny, createdTime=Sun Mar 21 08:43:38 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036534, encodeId=3ba810365346d, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 20 16:36:47 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949713, encodeId=a0ad949e1364, content=想看个原文真是费尽心血, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210320/b37509b5a7b2414586f8a02a8c0bbac5/4a4423496ce64105b7466d719b7718d4.jpg, createdBy=27b85459409, createdName=ms2000000903172319, createdTime=Sat Mar 20 14:52:24 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
2021-03-22 zhyy91

#病毒变异#

62 0
[GetPortalCommentsPageByObjectIdResponse(id=1937998, encodeId=fbf6193e99826, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 11 22:36:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305240, encodeId=221d130524091, content=<a href='/topic/show?id=ba392659e58' target=_blank style='color:#2F92EE;'>#体检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26597, encryptionId=ba392659e58, topicName=体检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321264, encodeId=5922132126437, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342796, encodeId=2f501342e963f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491056, encodeId=06231491056a1, content=<a href='/topic/show?id=a63ce0908b3' target=_blank style='color:#2F92EE;'>#病毒变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70908, encryptionId=a63ce0908b3, topicName=病毒变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a528868216, createdName=zhyy91, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535801, encodeId=ebdb15358011a, content=<a href='/topic/show?id=0e8a551866c' target=_blank style='color:#2F92EE;'>#抗体检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55186, encryptionId=0e8a551866c, topicName=抗体检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682812619358, createdName=tongyongming, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949850, encodeId=6c3f949850fa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/1f3a8e64c4dc4559af4d21a37afef10a/3632634089c24e5c807a83138e2529ce.jpg, createdBy=c3d35445259, createdName=悠悠sunny, createdTime=Sun Mar 21 08:43:38 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036534, encodeId=3ba810365346d, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 20 16:36:47 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949713, encodeId=a0ad949e1364, content=想看个原文真是费尽心血, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210320/b37509b5a7b2414586f8a02a8c0bbac5/4a4423496ce64105b7466d719b7718d4.jpg, createdBy=27b85459409, createdName=ms2000000903172319, createdTime=Sat Mar 20 14:52:24 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
2021-03-22 tongyongming

#抗体检测#

80 0
[GetPortalCommentsPageByObjectIdResponse(id=1937998, encodeId=fbf6193e99826, content=<a href='/topic/show?id=02de15902d3' target=_blank style='color:#2F92EE;'>#SARS-CoV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15902, encryptionId=02de15902d3, topicName=SARS-CoV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Fri Jun 11 22:36:47 CST 2021, time=2021-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305240, encodeId=221d130524091, content=<a href='/topic/show?id=ba392659e58' target=_blank style='color:#2F92EE;'>#体检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26597, encryptionId=ba392659e58, topicName=体检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b191324, createdName=marongnuan, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1321264, encodeId=5922132126437, content=<a href='/topic/show?id=ac0d159007f' target=_blank style='color:#2F92EE;'>#SARS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15900, encryptionId=ac0d159007f, topicName=SARS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8306486, createdName=小刀医生, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342796, encodeId=2f501342e963f, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491056, encodeId=06231491056a1, content=<a href='/topic/show?id=a63ce0908b3' target=_blank style='color:#2F92EE;'>#病毒变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70908, encryptionId=a63ce0908b3, topicName=病毒变异)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a528868216, createdName=zhyy91, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535801, encodeId=ebdb15358011a, content=<a href='/topic/show?id=0e8a551866c' target=_blank style='color:#2F92EE;'>#抗体检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55186, encryptionId=0e8a551866c, topicName=抗体检测)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=682812619358, createdName=tongyongming, createdTime=Mon Mar 22 04:36:47 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949850, encodeId=6c3f949850fa, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210225/1f3a8e64c4dc4559af4d21a37afef10a/3632634089c24e5c807a83138e2529ce.jpg, createdBy=c3d35445259, createdName=悠悠sunny, createdTime=Sun Mar 21 08:43:38 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036534, encodeId=3ba810365346d, content=顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Sat Mar 20 16:36:47 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949713, encodeId=a0ad949e1364, content=想看个原文真是费尽心血, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210320/b37509b5a7b2414586f8a02a8c0bbac5/4a4423496ce64105b7466d719b7718d4.jpg, createdBy=27b85459409, createdName=ms2000000903172319, createdTime=Sat Mar 20 14:52:24 CST 2021, time=2021-03-20, status=1, ipAttribution=)]
2021-03-21 悠悠sunny

学习了

102 0
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2021-03-20 旺医

顶刊就是顶刊，谢谢梅斯带来这么高水平的研究报道，我们科里同事经常看梅斯，分享梅斯上的信息

84 0
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2021-03-20 ms2000000903172319

想看个原文真是费尽心血

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