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Ann Intensive Care:可逆性气流阻塞患者 经鼻高流量支气管扩张剂雾化吸入效果如何?

2019-02-21 王淳 环球医学

2018年12月,法国学者发表在《Ann Intensive Care》的一项随机交叉研究,考察了经鼻高流量支气管扩张剂雾化吸入的有效性。

2018年12月,法国学者发表在《Ann Intensive Care》的一项随机交叉研究,考察了经鼻高流量支气管扩张剂雾化吸入的有效性。

背景:目前缺乏对照临床数据显示,通过经鼻高流量治疗回路雾化后,支气管扩张剂的有效性。

结果:可逆阻塞性肺病成人患者定义为,上个月评估的基线第一秒用力呼气容积(FEV1)占肺活量的比率低于70%,且支气管舒张试验结果为阳性(吸入沙丁胺醇后FEV1至少增加12%和200 mL)。签订知情同意后,纳入可逆阻塞性肺病成人患者。非入组标准为持续恶化、咯血、不能控制的哮喘、近期气胸、肺或胸膜活检、支气管肺泡灌洗、妊娠、母乳喂养、托管、监护和沙丁胺醇过敏或不耐受。

25名可逆气流阻塞患者按随机顺序接受了:(1)沙丁胺醇2.5mg,面罩喷射式雾化器给药;(2)沙丁胺醇2.5mg,通过安装在鼻腔高流量加湿室下游的振动筛网雾化器给药(30L/min和37℃);(3)无雾化经鼻高流量治疗。与基线相比,所有3种状况都使个体一秒钟用力呼气量(FEV1)显着增加。面罩雾化后(+350mL(+180;+550);+18%(+8;+30))和经鼻高流量雾化后(+330mL(+140;+390);+16%(+5;+24))的中位改变相似(p=0.11)。然而,无雾化经鼻高流量治疗后显着降低(+50mL(-10;+220);+3%(-1;+8);p=0.0009)。面罩和经鼻高流量雾化后FEV1增加且剩余体积的降低良好相关(p<0.0001和p=0.01)。两种技术在气流阻塞可逆性方面表现出良好的一致性(kappa 0.60)。

结论:鼻腔高流量振动筛网雾化吸入沙丁胺醇,可诱导与标准面罩喷射式雾化相似的支气管扩张。除了药物性支气管扩张,经鼻高流量其本身也会诱导小幅但显着的支气管扩张。

原始出处:

Reminiac F, et al. Nasal high-flow bronchodilator nebulization: a randomized cross-over study. Ann Intensive Care. 2018 Dec 20;8(1):128. doi: 10.1186/s13613-018-0473-8.

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    2019-03-24 lsj637
  8. [GetPortalCommentsPageByObjectIdResponse(id=1696872, encodeId=25a416968e29d, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Wed Nov 20 23:43:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039027, encodeId=6baf203902e76, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Mon Mar 04 21:43:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892190, encodeId=f9b21892190fb, content=<a href='/topic/show?id=1b445e1232d' target=_blank style='color:#2F92EE;'>#支气管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57123, encryptionId=1b445e1232d, topicName=支气管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Fri May 03 06:43:00 CST 2019, time=2019-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943144, encodeId=c5f21943144bb, content=<a href='/topic/show?id=01115e14261' target=_blank style='color:#2F92EE;'>#支气管扩张剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57142, encryptionId=01115e14261, topicName=支气管扩张剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Fri Oct 18 23:43:00 CST 2019, time=2019-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457740, encodeId=280c145e740c4, content=<a href='/topic/show?id=e2d1988611e' target=_blank style='color:#2F92EE;'>#雾化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98861, encryptionId=e2d1988611e, topicName=雾化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Sat Feb 23 05:43:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580248, encodeId=5b191580248d6, content=<a href='/topic/show?id=76743853197' target=_blank style='color:#2F92EE;'>#可逆性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38531, encryptionId=76743853197, topicName=可逆性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=023016601943, createdName=小华子, createdTime=Sat Feb 23 05:43:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1684775, encodeId=d63e1684e75f2, content=<a href='/topic/show?id=794754e74f4' target=_blank style='color:#2F92EE;'>#扩张#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54774, encryptionId=794754e74f4, topicName=扩张)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=699d28086811, createdName=lsj637, createdTime=Sun Mar 24 22:43:00 CST 2019, time=2019-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046757, encodeId=7a2a1046e5752, content=疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Thu Feb 21 17:43:00 CST 2019, time=2019-02-21, status=1, ipAttribution=)]
    2019-02-21 CHANGE

    疗效只是效果的众多方面之一,还要看对患者的获益,包括生活质量等因素共同决定效果的

    0

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