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Braz Oral Res:浓缩生长因子和脱细胞真皮基质的成骨作用的比较

2019-02-16 不详 网络

浓缩生长因子(CGF)是一种自生产品,含有高浓度的血小板,可通过选择性离心从静脉血中获得。据推测,人血小板中的局部生长因子(胰岛素样生长因子,IGF;转化生长因子,TGF-β;血小板衍生生长因子,PDGF)将增强移植物的愈合且还抵消再吸收。本研究评估了CGF和脱细胞真皮基质(ADM)对牙槽突缺损的成骨作用。将20个牙槽突裂患者随机分为两组。一组采用脱细胞真皮基质膜结合髂嵴骨移植(GBR组)进行牙槽

浓缩生长因子(CGF)是一种自生产品,含有高浓度的血小板,可通过选择性离心从静脉血中获得。据推测,人血小板中的局部生长因子(胰岛素样生长因子,IGF;转化生长因子,TGF-β;血小板衍生生长因子,PDGF)将增强移植物的愈合且还抵消再吸收。本研究评估了CGF和脱细胞真皮基质(ADM)对牙槽突缺损的成骨作用。

将20个牙槽突裂患者随机分为两组。一组采用脱细胞真皮基质膜结合髂嵴骨移植(GBR组)进行牙槽骨移植,引导骨再生(GBR),另一组采用牙槽骨移植联合CGF(CGF组)。在手术后1周和6个月获得锥束计算机断层扫描(CBCT)图像。使用Mimics 17.0软件,计算骨吸收率和骨密度改善率,并在两组之间进行比较。结果显示,虽然ADM和CGF在骨吸收率方面不明显,但CGF病例(61.62±4.728%)的骨密度改善明显优于ADM(27.05±5.607%)(p = 0.0002)。

因此,可将CGF推荐给患有牙槽突裂的患者作为更好的选择。

原始出处:

Huang L, Zou R, et al., Comparing osteogenic effects between concentrated growth factors and the acellular dermal matrix. Braz Oral Res. 2018;32:e29. doi: 10.1590/1807-3107bor-2018.vol32.0029. Epub 2018 May 3.

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    2019-12-13 小几洁
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    2019-02-18 zhaojie88
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