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Neurology:改善患有视神经脊髓炎妇女的妊娠结局非常重要

2015-11-20 MedSci MedSci原创

目的:本研究评估了视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorder,NMOSD)与妊娠结果之间的关系。 方法:在这项回顾性研究中,研究人员收纳了60名被诊断为NMOSD的女性患者,且至少有一次妊娠史的女性患者。利用多元逻辑回归分析妊娠期间NMOSD发病是否与增加患者流产或先兆子痫发病风险有关。 研究结果:妊娠期间患NMOSD的患者流产率高(42

目的:本研究评估了视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorder,NMOSD)与妊娠结果之间的关系。

方法:在这项回顾性研究中,研究人员收纳了60名被诊断为NMOSD的女性患者,且至少有一次妊娠史的女性患者。利用多元逻辑回归分析妊娠期间NMOSD发病是否与增加患者流产或先兆子痫发病风险有关。

研究结果:妊娠期间患NMOSD的患者流产率高(42.9%(95% CI 95% - 17.7%)和7.04%(2.33% - -15.7%)),在怀孕在起病的前后三年内,患NMOSD患者流产风险增加(优势比分别为7.28(1.03 - -51.6)和11.6 [1.05–128]),与正常妊娠相比,女性在疾病开始后一年的时间内流产,妊娠前九个月疾病活动更明显(平均复发率分别为0.707 vs 0.100),先兆子痫的发病率(11.5% [6.27%–18.9%])也显著增高。先兆子痫的概率在患有其他自身免疫性疾病或在最近一次妊娠中出现流产的女性中几率较大,但是发病本身不是一个危险因素。

结论:在NMOSD发病后怀孕与流产是一个相对独立危险因素,高疾病活动可能会增加流产风险,所以,在孕前及孕期防治疾病活动,对于改善患有视神经脊髓炎妇女的妊娠结局是十分重要。

原始出处

Matthew M. Nour, BM, BCh, Ichiro Nakashima, MD, PhD, Ester Coutinho.et.al.Pregnancy outcomes in aquaporin-4–positive neuromyelitis optica spectrum disorder.Neurology.2015

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    2016-06-09 gj0740
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    2016-09-02 yinhl1978
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