Baidu
map

JAHA:NT-proBNP与房颤发生风险种族差异相关

2019-03-27 不详 MedSci原创

黑种人的心血管疾病风险因素要多于白种人,但房颤的发生率却低于白种人,相反,白种人的心衰风险更低。在白人中,N末端前B型钠尿肽(NT-proBNP)水平较高,可预测房颤的发生,并在心室舒张压升高的情况下具有利尿作用,这可能为这些种族差异提供统一的解释。本研究纳入了4731名CHS临床研究中参与者(770名黑种人)和12418名ARIC临床研究的参与者(3091名黑种人),其中分别有1277名和125

黑种人的血管疾病风险因素要多于白种人,但房颤的发生率却低于白种人,相反,白种人的心衰风险更低。在白人中,N末端前B型钠尿肽(NT-proBNP)水平较高,可预测房颤的发生,并在心室舒张压升高的情况下具有利尿作用,这可能为这些种族差异提供统一的解释。

本研究纳入了4731名CHS临床研究中参与者(770名黑种人)和12418名ARIC临床研究的参与者(3091名黑种人),其中分别有1277名和1253名房颤患者。与黑种人相比,白种人基线NT-proBNP水平更高,房颤的发生风险也更高。NT-proBNP水平可以解释房颤风险的种族差异。与假设不一致的是,尽管CHS临床研究中白种人的心衰风险更低,但在ARIC临床研究中无统计学差异。

研究结果显示,房颤发生风险的种族差异可以由基线NT-proBNP水平的差异解释。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1268102, encodeId=23c01268102ea, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289323, encodeId=b8c61289323ab, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290352, encodeId=1605129035279, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353581, encodeId=26d81353581b1, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602138, encodeId=8a4f160213852, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=)]
    2019-03-29 zhaohui6731
  2. [GetPortalCommentsPageByObjectIdResponse(id=1268102, encodeId=23c01268102ea, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289323, encodeId=b8c61289323ab, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290352, encodeId=1605129035279, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353581, encodeId=26d81353581b1, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602138, encodeId=8a4f160213852, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=)]
    2019-03-29 huiwelcome
  3. [GetPortalCommentsPageByObjectIdResponse(id=1268102, encodeId=23c01268102ea, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289323, encodeId=b8c61289323ab, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290352, encodeId=1605129035279, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353581, encodeId=26d81353581b1, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602138, encodeId=8a4f160213852, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=)]
    2019-03-29 mjldent
  4. [GetPortalCommentsPageByObjectIdResponse(id=1268102, encodeId=23c01268102ea, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289323, encodeId=b8c61289323ab, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290352, encodeId=1605129035279, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353581, encodeId=26d81353581b1, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602138, encodeId=8a4f160213852, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1268102, encodeId=23c01268102ea, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289323, encodeId=b8c61289323ab, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290352, encodeId=1605129035279, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353581, encodeId=26d81353581b1, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602138, encodeId=8a4f160213852, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Fri Mar 29 06:33:00 CST 2019, time=2019-03-29, status=1, ipAttribution=)]
    2019-03-29 sunylz

相关资讯

JAHA:血浆金属蛋白酶-1水平与慢性肾脏疾病呈相关性

组织抑制剂金属蛋白酶-1(timp-1)和原胶原III型氨基末端肽是细胞外基质重塑的循环标志物,与心血管疾病的发生有关。这两种标志物与充血性心衰和慢性肾脏疾病(CKD)的相关性尚不清楚。本研究纳入了922名参与者(平均年龄57岁,女性占57%),并对其血浆的timp-1和原胶原III型氨基末端肽水平进行了检测。分析结果显示,血浆的timp-1水平与CKD的发生呈正相关(HR:1.90; 95% C

JACC:前100例经导管二尖瓣置换术患者的随访研究

经导管二尖瓣置换术(TMVR)是一项发展迅速的技术,而接受TMVR治疗的患者的随访资料尚缺乏。本研究的目的旨在评估前100名接受TMVR治疗的患者的随访预后。本研究纳入了100例外科手术高风险二尖瓣反流患者,平均年龄 75.4±8.1岁,男性占69%。在这些患者中,严重心衰(66%)和左室功能不全(平均射血分数46.4±9.6%)的发生率较高。在TMVR过程中,无1例死亡,有1例心尖大出血,无急性

盘点:JACC三月第三期研究一览

1.直接口服抗凝药物对二尖瓣狭窄患者的影响DOI: 10.101

JACC:经导管经中隔二尖瓣置换术安全可行

严重的二尖瓣反流(MR)的发病率和死亡率较高,外科修复术有时候可能并不合适。本研究的目的旨在评价经皮经中隔经导管二尖瓣置换术(TMVR)系统的可行性。该系统首次应用在人类,包括一个环绕腱索的镍钛醇基座和一个可扩张的球囊经导管心脏瓣膜。主要的病例入组标准为严重的MR且伴外科手术高风险,排除标准为左室射血分数<30%,或者心脏解剖不合适。主要终点事件为技术成功,次要终点事件为术后30天无死亡、卒中和瓣

JACC:TAVR对严重主动脉瓣狭窄患者住院率的影响

严重主动脉瓣狭窄(AS)患者的再住院率较高。本研究的目的旨在评估经导管主动脉瓣置换术(TAVR)对严重AS患者再住院率的影响。本研究纳入了15324名接受TAVR治疗的患者,平均年龄为84岁,平均胸外科医师学会预测死亡率风险评分为7.0,61.1%的患者是通过经股途径接受TAVR。与接受TAVR治疗之前相比,接受TAVR治疗后的心衰住院率和住院天数均有所下降。然而,全因、非心血管和出血住院率和住院

JACC:阻断脂质诱导的综合应激反应可减少动脉粥样硬化

真核细胞可以通过在真核起始因子2α(eIf2α)上丝氨酸-51磷酸化处聚集来对多种刺激作出反应,并激活整合应激反应(ISR),然而,在人和小鼠的动脉硬化过程中,eIf2α的磷酸化一直存在。本研究的目的旨在评估在慢性代谢和炎症性疾病动脉粥样硬化中截获ISR的潜在益处。 本研究利用3种不同的小分子和ATP模拟敏感激酶等位基因技术,在多个分子节点上阻断ISR,研究了ISR在脂质诱导炎症激活和动

Baidu
map
Baidu
map
Baidu
map