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Stroke:动脉瘤性蛛网膜下腔出血患者额叶激活增强

2016-10-04 xing.T MedSci原创

该研究已经证实在执行任务过程中为取得好的表现,前扣带回和前基底区域激活更加明显,前扣带回激活程度与认知(蒙特利尔认知评价)评分呈负相关。

神经认知功能缺陷在动脉瘤性蛛网膜下腔出血的患者很是常见,即使在那些预后较好而且没有结构性病变患者中也较为普遍。近日,卒中领域权威杂志《Stroke》上发表了一篇研究文章,旨在探讨颅内动脉瘤破裂患者认知功能障碍的神经生理基础。

在研究中,研究者纳入了13例单纯栓塞治疗的动脉瘤性蛛网膜下腔出血患者以及13例匹配的对照者,所有研究对象在神经心理学测试之前均进行头颅核磁扫描。静息状态下,头颅核磁扫描采用151通道进行数据采集,另外,进行2个认知功能检查(go-no-go任务和定式转换任务),从治疗到测试的平均时间为18.8个月。

通过抑制性认知任务(go-no-go任务),研究者发现患者右侧前扣带回和额下回明显激活,而通过认知定势转移任务(心理灵活性)发现,动脉瘤性蛛网膜下腔出血的患者双侧前扣带回皮层和右侧额内侧回也明显激活,两组间激活的时间也有明显不同。在静息状态下,前扣带回的β带连接与蒙特利尔认知评估量表得分呈负相关(左:r =−0.56;P<0.01;右:r =−0.55;P<0.01)。这一区域的高连通性与较差的认知测试表现相关。

该研究已经证实在执行任务过程中为取得好的表现,前扣带回和前基底区域激活更加明显,前扣带回激活程度与认知(蒙特利尔认知评价)评分呈负相关。

原始出处:

Leodante da Costa, et al. Increased Frontal Lobe Activation After Aneurysmal Subarachnoid Hemorrhage. Stroke. 2016.

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    2016-10-05 1e0d99ddm02(暂无匿称)

    脑肿瘤是引起脑出血一大因素!

    0

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    2016-10-04 医路开来

    很不错的文章,

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1654428, encodeId=1be01654428af, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Sat Apr 22 16:34:00 CST 2017, time=2017-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337792, encodeId=c795133e792b9, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Thu Oct 06 08:34:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140554, encodeId=f29914055430, content=脑肿瘤是引起脑出血一大因素!, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Wed Oct 05 20:33:09 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140232, encodeId=1be8140232ff, content=很不错的文章,, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:59:42 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140231, encodeId=0bac1402313a, content=谢谢分享,。, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:59:31 CST 2016, time=2016-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140230, encodeId=a3d4140230b9, content=学习啦,,, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Tue Oct 04 23:59:25 CST 2016, time=2016-10-04, status=1, ipAttribution=)]
    2016-10-04 医路开来

    谢谢分享,。

    0

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    2016-10-04 医路开来

    学习啦,,

    0

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