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J Rheumatol:伴高尿酸血症的银屑病关节炎特点和预后

2017-12-11 xiangting MedSci原创

高尿酸血症在PsA患者中很常见,尤其是病程较长、肥胖的银屑病患者。

这项研究旨在探讨伴高尿酸血症(HUC)的银屑病关节炎(PsA)患者的特点及其预后,尤其是心血管疾病(CVD)和肾脏疾病。

在PsA门诊按照标准方案对患者进行前瞻性随访,间隔6-12个月。将HUC定义为男性> 450μmol/ L或女性> 360μmol/ L。基于性别和年龄±5岁将HUC患者与正常尿酸患者进行匹配。分析了人口学信息和疾病特征。记录HUC患者的预后,特别是CVD和肾脏疾病。进行条件性logistic回归分析,以确定在PsA患者中与HUC独立相关的因素。

1019例PsA患者中有325例(31.9%)伴HUC。其中,318例与318例正常对照相匹配。325例HUC患者中有11例(3.4%)有痛风。HUC患者病程较长,银屑病面积和严重程度指数较高。他们有更多的合并症,包括CVD和代谢性疾病,以及肾结石和高肌酐的患病率高。第一次评估时只有1例HUC患者用别嘌醇治疗,随访期间有7例。随访中318例患者中有163例2次以上随访有持续性HUC(pHUC)。pHUC患者心肌梗塞、心力衰竭和肾损伤更常见。多变量分析显示pHUC、PsA病程和肥胖之间存在关联。

高尿酸血症在PsA患者中很常见,尤其是病程较长、肥胖的银屑病患者。正确控制HUC和代谢性疾病可能会对改善PsA预后起预防作用。

原始出处:
Roa'A AlJohani, et al. Characteristic and Outcome of Psoriatic Arthritis Patients with Hyperuricemia.  J Rheumatol. 1 December 2017. 

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    2018-02-20 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2017-12-11 stupidox

    不错,学习了。

    0

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    2017-12-11 戒馋,懒,贪

    谢谢分享学习了

    0

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