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Dig Dis Sci: 炎症性肠病不会影响死亡率,但会增加急性心肌梗死患者的住院时间

2021-01-27 MedSci原创 MedSci原创

炎性肠病(IBD)是一种由免疫介导的慢性组织损伤的胃肠道(GI)炎性病症,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。

       炎性肠病(IBD)是一种由免疫介导的慢性组织损伤的胃肠道(GI)炎性病症,主要包括溃疡性结肠炎(UC)和克罗恩病(CD)。由于其他免疫性疾病如类风湿关节炎(RA),银屑病,和系统性红斑狼疮与血管事件发生存在正相关性,因此,研究人员怀疑IBD的自身免疫特性与心血管(CV)事件的发生风险也存在相关性。而且,丹麦的一项全国性队列研究对86790例初发心梗(MI)的患者进行了研究,其中1030例患有IBD(75.9%UC和24.1%CD),发现MI时IBD发作与MI30内天复发风险增加相关。本项研究旨在调查IBD患者的心肌梗塞(MI)临床结局。

 

 

      研究人员使用1998年至2010年美国全国住院患者样本数据进行了横断面研究。对所有合格的MI患者比较了有或没有IBD诊断的临床结局。对数据进行单因素分析后,再校正混杂因素进行相关分析,使用多因素logistic回归确定UC和CD对院内MI死亡率的影响。

 

 

      本项研究共纳入2629161例MI患者,其中3607例UC和3784例CD患者。UC(OR,1.12; 95%CI 0.98–1.29)和CD(OR 0.99; 95%CI 0.86-1.15)都不影响MI患者的院内死亡率。合并或不合并UC的MI患者的院内死亡率(7.75%vs. 7.05%; p = 0.25)或合并或不合并CD的MI患者的院内死亡率之间没有差异(6.50%vs.6.59%; p = 0.87)。与非IBD患者相比,IBD患者的住院时间(LOS)更长,UC患者的医疗总费用更高($ 65182 vs. $ 53542;p <0.001)。

 

 

      本项研究通过回顾性分析表明,IBD不会影响心肌梗死的院内死亡率。但是,患有IBD的MI患者的LOS较长。UC患者的总住院费用要高于没有IBD的MI患者。

 

 

 

原始出处:

Preetika Sinh. Et al. Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction. Digestive Diseases and Sciences.2021.

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    2021-04-12 zhaojie88
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    2021-01-27 hfq

    0

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    2021-01-27 ms4000002029592022

    学习到了

    0

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