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J Med Biochem:鉴别社区获得性肺炎和慢阻肺急性加重,降钙素原和C反应蛋白有话说

2017-07-30 MedSci MedSci原创

众所周知,血清降钙素原(PCT)和C反应蛋白(CRP)是全身炎症反应和细菌感染的标志物。本研究中我们的目的是比较降钙素原和C反应蛋白在鉴别社区获得性肺炎和慢性阻塞性肺疾病(COPD)急性加重期的作用。

众所周知,血清降钙素原(PCT)和C反应蛋白(CRP)是全身炎症反应和细菌感染的标志物。本研究中我们的目的是比较降钙素原和C反应蛋白在鉴别社区获得性肺炎和慢性阻塞性肺疾病(COPD)急性加重期的作用。

研究共纳入116例患者:其中76例为慢性阻塞性肺疾病,定义为1组;40例为社区获得性肺炎,定义为2组。

研究结果显示,COPD组平均CRP水平为44mg/L,肺炎组为132 mg/L;COPD组血清PCT的中位数为0.07 ng/mL,肺炎组为0.14 ng/mL。所以说,与COPD组相比,肺炎组的血清PCT和CRP水平均显著升高(p<0.001)。肺炎组CRP的ROC曲线下面积为0.788(CI:0.704-0.872),PCT为(CI:0.599-0.800)。

所以我们可以得出结论:于急诊科就诊的社区获得性肺炎患者血清降钙素原和C反应蛋白水平显著高于慢性阻塞性肺疾病急性加重期患者。同时血清C反应蛋白浓度和降钙素原浓度呈强相关性。因此,C反应蛋白可能是诊断下呼吸道感染患者一个更有价值的生物标志物。

原始出处:

Colak A1, Yilmaz C2, et al. Procalcitonin and CRP as Biomarkers in Discrimination of Community-acquired Pneumonia and Exacerbation of COPD. J Med Biochem. 2017 Apr 22;36(2):122-126. doi: 10.1515/jomb-2017-0011. eCollection 2017 Apr.

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    2017-08-22 sunylz
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    2017-11-02 杏林一叶

    CRP增高见于多种情况.包括感染和非感染.即特异性不强.

    0

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    2017-07-30 137****9095

    henhao

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