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Prog Biomater:PCL/明胶/壳聚糖/β-TCP电纺复合物可有效用于引导骨组织再生术

2018-11-06 MedSci MedSci原创

既往已经开发了许多方法来再生生物替代物以修复受损组织。近年来,采用屏障膜的引导骨/组织再生(GBR/GTR)受到了很多关注,但是仍缺乏十分有效的治疗策略。本研究旨在制造由聚己内酯(PCL)/明胶/壳聚糖组成的GBR膜,实用不同百分比的β-磷酸三钙(β-TCP)改性,以改善生物相容性、机械性能和抗菌活性。检查膜的机械性能、表面粗糙度、亲水性、生物降解性和生物响应。结果显示,随着β-TCP含量的增加,

既往已经开发了许多方法来再生生物替代物以修复受损组织。近年来,采用屏障膜的引导骨/组织再生(GBR/GTR)受到了很多关注,但是仍缺乏十分有效的治疗策略。

本研究旨在制造由聚己内酯(PCL)/明胶/壳聚糖组成的GBR膜,实用不同百分比的β-磷酸三钙(β-TCP)改性,以改善生物相容性、机械性能和抗菌活性。检查膜的机械性能、表面粗糙度、亲水性、生物降解性和生物响应。

结果显示,随着β-TCP含量的增加,膜的机械性能、润湿性和粗糙度得到改善。随着β-TCP的量增加至5%(145-200MPa),基材的弹性模量增加。5小时后,在具有1%,3%和5%β-TCP的膜上,附着细胞的数量分别增加30%,40%和50%。与没有β-TCP和5%β-TCP相比,3%β-TCP的膜上的细胞生长也分别的细胞高50%和20%。随着β-TCP增加至3%,I型胶原的表达增加,而ALP活性没有差异。

综上所述,该研究结果表明,3%β-TCP的复合物具有引导骨组织再生的潜在应用。

原始出处:

Masoumeh Ezati, Hamide Safavipour, et al., Development of a PCL/gelatin/chitosan/β-TCP electrospun composite for guided bone regeneration. Prog Biomater. 2018 Sep; 7: 225–237.

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    2019-03-28 sunylz
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    2018-11-08 showtest
  5. [GetPortalCommentsPageByObjectIdResponse(id=1910624, encodeId=5c1e1910624f9, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Nov 13 15:39:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076349, encodeId=3dff20e63492f, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Aug 19 00:39:00 CST 2019, time=2019-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918377, encodeId=50c919183e7f3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Mar 28 16:39:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486577, encodeId=c91f14865e7f7, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582422, encodeId=c3de158242211, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591993, encodeId=291815919939a, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602075, encodeId=f42b16020e52e, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1910624, encodeId=5c1e1910624f9, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Nov 13 15:39:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076349, encodeId=3dff20e63492f, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Aug 19 00:39:00 CST 2019, time=2019-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918377, encodeId=50c919183e7f3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Mar 28 16:39:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486577, encodeId=c91f14865e7f7, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582422, encodeId=c3de158242211, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591993, encodeId=291815919939a, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602075, encodeId=f42b16020e52e, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1910624, encodeId=5c1e1910624f9, content=<a href='/topic/show?id=b45b426195e' target=_blank style='color:#2F92EE;'>#复合物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42619, encryptionId=b45b426195e, topicName=复合物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Tue Nov 13 15:39:00 CST 2018, time=2018-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076349, encodeId=3dff20e63492f, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Aug 19 00:39:00 CST 2019, time=2019-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1918377, encodeId=50c919183e7f3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Thu Mar 28 16:39:00 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486577, encodeId=c91f14865e7f7, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582422, encodeId=c3de158242211, content=<a href='/topic/show?id=bda942398cd' target=_blank style='color:#2F92EE;'>#壳聚糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42398, encryptionId=bda942398cd, topicName=壳聚糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f716920725, createdName=dlwang_26703132, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591993, encodeId=291815919939a, content=<a href='/topic/show?id=595ce765983' target=_blank style='color:#2F92EE;'>#组织再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77659, encryptionId=595ce765983, topicName=组织再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e818060478, createdName=sunyl13, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602075, encodeId=f42b16020e52e, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Nov 08 11:39:00 CST 2018, time=2018-11-08, status=1, ipAttribution=)]
    2018-11-08 sunylz
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