Br J Clin Pharmacol.：类风湿性关节炎病人用药剂量不能一刀切

2016-12-29 佚名生物谷

过去十年间，生物制剂的广泛使用显著改变了类风湿性关节炎的治疗方案，这些产自人体或动物的生物制剂成为了许多病人的基本治疗方案。但与此同时，这些生物制剂包含大量作用机理不同的单克隆抗体，优化治疗方案往往是医生面临的挑战之一。药企往往推荐比较传统的给药方案：采用同一剂量治疗所有病人。但是一项最新的医学研究综述表明不同病人血液中的生物制剂浓度差别较大，这可能影响治疗疗效。因此现在需要修正这种传统

过去十年间，生物制剂的广泛使用显著改变了类风湿性关节炎的治疗方案，这些产自人体或动物的生物制剂成为了许多病人的基本治疗方案。但与此同时，这些生物制剂包含大量作用机理不同的单克隆抗体，优化治疗方案往往是医生面临的挑战之一。

药企往往推荐比较传统的给药方案：采用同一剂量治疗所有病人。但是一项最新的医学研究综述表明不同病人血液中的生物制剂浓度差别较大，这可能影响治疗疗效。因此现在需要修正这种传统的给药理念：医生应该优化不同病人的给药剂量，以个性化治疗提高治疗效果。

“这些药物广泛使用，因此很有必要研究可能影响血清药物浓度的因素及共变量，这有利于我们优化或预测药物代谢动力学，”作者在这篇发表在《英国临床药理学杂志》的综述中写道。“更重要的是，在临床上使用群体性药代动力学模型有利于我们为病人选择疗效最佳且费用较低的给药剂量。”

原始出处

Bastida C1, Ruíz V2, Pascal M3, Yagüe J4, Sanmartí R5, Soy D1.Is there potential for Therapeutic Drug Monitoring of Biologic Agents in Rheumatoid Arthritis? British Journal of Clinical Pharmacology.2016 Dec 19

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2017-06-28 dingxiaobo

#Pharmacol#

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2017-01-04 chentianping

#pharma#

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2017-11-26 jj000001

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2017-12-01 yb6560

#MAC#

64 0
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2016-12-31 lmm397

#关节炎#

80 0
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2016-12-31 ms4964546379600229

#类风湿#

63 0
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2016-12-31 ms1467340776200723

#风湿性关节炎#

74 0

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