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IBD: 人疱疹病毒感染是溃疡性结肠炎行结肠切除术的危险因素

2018-06-03 MedSci MedSci原创

对于炎症性肠病(IBD)患者,我们对其患有除巨细胞病毒(CMV)以外的人类疱疹病毒的流行和致病性知之甚少。本研究的目的是确定人类疱疹病毒在IBD患者结肠黏膜中的流行情况,并评估这些患者的长期预后。

背景
对于炎症性肠病IBD)患者,我们对其患有除巨细胞病毒(CMV)以外的人类疱疹病毒的流行和致病性知之甚少。本研究的目的是确定人类疱疹病毒在IBD患者结肠黏膜中的流行情况,并评估这些患者的长期预后。

方法
我们使用多重聚合酶链式反应(PCR)技术检查了66名患有溃疡性结肠炎(UC),54名克罗恩病(CD)患者和29名健康患者的结肠粘膜标本,以鉴定6种最常见类型的人疱疹病毒。

结果
单纯疱疹病毒(HSV)-1/2和水痘 - 带状疱疹病毒(VZV)未在任何组中检测到。在UC患者中EB病毒(EBV)(21.2%)和CMV(15.1%)的患病率高于CD患者(EBV 9.3%,CMV 0%)和健康对照组(EBV 0%,CMV 3.4%)。人类疱疹病毒(HHV)-6A / B和HHV-7的发病率在各组之间没有统计学差异。五名炎症性UC患者共存CMV和EBV或HHV-6。CMV与EBV或HHV-6的联合感染是UC患者随后结肠切除术的显着和独立的预后因素。

结论
伴有EBV / HHV-6感染的CMV患病率增加与UC患者的临床病程有关。

原始出处:

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    2018-10-26 nymo
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    2018-06-05 bnurmamat
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    2018-06-05 heli0118
  6. [GetPortalCommentsPageByObjectIdResponse(id=1706548, encodeId=61e31e06548d5, content=<a href='/topic/show?id=0df2e87477d' target=_blank style='color:#2F92EE;'>#结肠切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78747, encryptionId=0df2e87477d, topicName=结肠切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a89f31292094, createdName=12498568m60暂无昵称, createdTime=Fri Sep 14 22:06:00 CST 2018, time=2018-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877030, encodeId=959618e70308c, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Thu Dec 27 21:06:00 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695025, encodeId=2f261695025d2, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Fri Oct 26 14:06:00 CST 2018, time=2018-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263475, encodeId=084612634e543, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Tue Jun 05 08:06:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580410, encodeId=886f15804107c, content=<a href='/topic/show?id=c026e05485f' target=_blank style='color:#2F92EE;'>#疱疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70548, encryptionId=c026e05485f, topicName=疱疹)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Jun 05 08:06:00 CST 2018, time=2018-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=321190, encodeId=7848321190f4, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Jun 03 17:45:02 CST 2018, time=2018-06-03, status=1, ipAttribution=)]
    2018-06-03 惠映实验室

    学习了.谢谢分享.

    0

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