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Clinica Chimica Acta:发热血小板减少综合征患者血清细胞因子及临床特点

2019-09-13 gladiator MedSci原创

本研究的目的探讨发热和血小板减少症的临床、微生物学和免疫学特点。<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:"Calibri","sans-serif"; mso-fareast-font-family:宋体;mso-bidi-font-f

本研究的目的探讨发热和血小板减少症的临床、微生物学和免疫学特点。

研究通过纳入不明原因发热和血小板减少症患者。采用实时PCR法检测病毒,培养法检测细菌。同时采用ELISA法检测血清细胞因子、血小板抗体IgG (PA-IgG)和幽门螺杆菌(HP)

研究显示,74.68%的患者可检出病原菌,包括真菌/病毒/细菌感染和多重感染。但25.32%的病例中病原体不能被识别。在患者与健康对照组相比,细胞因子包括白介素(IL) 6IL - 10 interferon-γ(IFN-γ)、血小板激活因子(PAF)参谋长和PA-IgG显著升高(P<.01P<.05)。主成分分析提取到4组具有较强阳性预测价值的参数,表明如果将血小板参数与炎症标志物结合使用,对病情的评估将更加准确。无事件生存(EFS)(表明治疗后血小板升高的时间)在单个细菌或真菌感染患者中最高,而EFS受细胞因子和PA-IgG水平的影响。

本研究表明,免疫功能的差异可能是影响发热、血小板减少症患者预后的主要因素,而准确的病因诊断是治疗效果的重要依据。

原始出处:

Huanzhu ChenChun LinSerum cytokines and clinical features in patients with fever and thrombocytopenia syndrome

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 


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    2020-02-12 windight
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