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Rheumatology:纤维肌痛患者非腹腔麸质敏感性的患病率和对无麸质饮食反应的评估

2022-08-03 紫菀款冬 MedSci原创

确定纤维肌痛患者队列中非腹腔麸质敏感性的患病率,并评估其对六周无麸质饮食的临床反应、症状的改善情况,不符合NCGS诊断标准的饮食反应者百分比,以及与饮食反应和诊断标准符合相关的基线特征

目的:确定纤维肌痛患者队列中非腹腔麸质敏感性(NCGS)的患病率,并评估其对六周无麸质饮食(GFD)的临床反应、症状的改善情况,不符合NCGS诊断标准的饮食反应者百分比,以及与饮食反应和诊断标准符合相关的基线特征。

 

方法:对一家专科医院的纤维肌痛患者队列进行非对照前瞻性实验研究。分析了患者百分比,项目包括符合Salerno专家标准、对GFD有反应、改善的与GFD反应和符合诊断标准相关的症状学和基线特征。

结果:共有142例患者入选,观察到NCGS患病率为5.6%。21.8%因肠道症状改善而对GFD有反应。74.2%的有反应者不符合Salerno专家标准。腹泻、上皮内淋巴细胞增多和较低的焦虑水平是GFD反应的预测因素。由于谷蛋白和安慰剂之间的鉴别器数量较少,因此未发现符合NCGS标准的预测因素

结论:该研究发现NCGS患病率与普通人群中的估计患病率相似。虽然可以对腹泻或上皮内淋巴细胞增多症患者进行评估,以评价其肠道症状是否有所改善,但不能系统地向所有纤维肌痛患者推荐GFD

文献来源:

Almirall M, Casellas F, Dot J, et al. Prevalence of non-celiac gluten sensitivity and assessment of the response to gluten-free diet in a cohort of patients with fibromyalgia [published online ahead of print, 2022 Jul 28]. Rheumatology (Oxford). 2022;keac434. doi:10.1093/rheumatology/keac434

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纤维肌痛(FM)患者的认知功能受损,身体活动减少,抑郁症状更加明显。虽然体育活动和运动疗法通常不是这种综合征的标准治疗方法的一部分,但越来越多的证据表明,经常参加消耗体力的活动有益于FM患者的心理功能

Journal of Pain Research:普瑞巴林在治疗中国人群纤维肌痛的疗效和安全性

在中国,纤维肌痛(FM)可能未得到充分诊断和治疗,部分原因是缺乏对该疾病的认识和理解,以及可用的治疗方法有限。

PLoS One:纤维肌痛症患者听力损失的风险:一项回顾性队列研究

在近期发表在PLoS One期刊的一项研究中,来自越南Duy Tan大学、中国医药大学等单位的科学家们研究了患有纤维肌痛症(FM)的患者是否比不患有纤维肌痛症的患者有更高的听力损失(HL)风险,并探讨

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