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Sci Rep:标准化前列腺周脂肪MRI测量可以预测经历根治性前列腺切除术男性的前列腺癌的侵入性

2017-07-05 AlexYang MedSci原创

之前的研究表明,前列腺周和骨盆脂肪可以通过旁分泌模式的趋化激素和生长因子的分泌来影响前列腺癌的行为。最近,有研究人员测量了在盆腔磁共振成像(MRI)上正常化前列腺体积的体外脂肪体积(PFV),并且将PFV与等级(格林森得分;GS)和根治性前列腺切除术(RP)后前列腺癌的病理阶段(pT)联系起来。另外,研究人员使用从前列腺基底到顶点的连续T1加权轴向MRI切片上的分割技术确定PFV。腹部脂肪面积(A

之前的研究表明,前列腺周和骨盆脂肪可以通过旁分泌模式的趋化激素和生长因子的分泌来影响前列腺癌的行为。最近,有研究人员测量了在盆腔磁共振成像(MRI)上正常化前列腺体积的体外脂肪体积(PFV),并且将PFV与等级(格林森得分;GS)和根治性前列腺切除术(RP)后前列腺癌的病理阶段(pT)联系起来。另外,研究人员使用从前列腺基底到顶点的连续T1加权轴向MRI切片上的分割技术确定PFV。腹部脂肪面积(AFA)和皮下脂肪厚度分别利用肚脐水平的T1加权轴切片和耻骨联合的上部边缘来进行测量。PFV被归一化到前列腺体积(PV),以解释PV的变化(NPFV?=?PFV/PV)。

另外,根据手术后的格林森得分:小于或等于6、7(3+4)和大于或等于7,将病人分成三个风险小组。研究发现,NPFV在不同的小组间具有显著的差异(p=0.001),并且与术后的格林森得分呈正相关关系(ρ=0.294, p<0.001)。更多的是,在前列腺癌低等级病人(1.99±0.82; n=17)和那些具有升级的前列腺切除术后格林森得分为6的病人(2.43±0.98; n=26)比较中,NPFV表现出差异,但是,这个差异并没有达到统计学上的显著性(p=0.11)。

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    2017-07-07 jeanqiuqiu
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    2017-07-06 189****7206

    学习了受益匪浅

    0

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    2017-07-05 1e1b8538m79(暂无匿称)

    不错的文章,值得一读

    0

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James B. Yu,Yale School of  Medicine, New Haven, CT本刊负责人:叶定伟;审校:张凯;翻译:邱红前列腺外照射治疗研究进展虽然缓慢,但仍然持续稳定地进行:获益和风险的辩证关系是前列腺癌外照射治疗研究深入的关键点。关于外照射剂量及分割次数的研究可能不如最新的小分子或全基因组分析那么诱人,但它们具有重要意义,研究成果可迅速应用于临床。前列腺癌

Nat Commun: 剪切变体揭开前列腺癌研究新篇章

实验结果显示了RNA剪切变体可能成为前列腺癌治疗中新的分子标志物和分子靶标,并在未来的研究和临床应用中发挥出巨大的潜力。

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