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Int J Nanomed:氧化石墨稀支架或可用于牙周组织工程

2018-05-02 MedSci MedSci原创

三维支架在牙周组织工程治疗中骨组织的体积和质量恢复中起关键作用。我们制造了一种新型3D胶原支架,其中含有碳基二维层状材料(氧化石墨烯 GO )。本研究旨在描述和评估GO支架在犬Ⅱ类根分叉病变中的骨组织的愈合效果。通过使用GO分散体涂覆在3D胶原海绵支架的表面制备GO支架。使用细胞毒性和组织反应性测试来表征支架。最后将GO支架植入犬II类根分叉病变的缺损中,术后4周探究牙周愈合情况。结果显示,GO支

三维支架在牙周组织工程治疗中骨组织的体积和质量恢复中起关键作用。我们制造了一种新型3D胶原支架,其中含有碳基二维层状材料(氧化石墨烯 GO )。本研究旨在描述和评估GO支架在犬Ⅱ类根分叉病变中的骨组织的愈合效果。

通过使用GO分散体涂覆在3D胶原海绵支架的表面制备GO支架。使用细胞毒性和组织反应性测试来表征支架。最后将GO支架植入犬II类根分叉病变的缺损中,术后4周探究牙周愈合情况。

结果显示,GO支架表现出低细胞毒性和增强的细胞向内生长和骨形成能力。另外,GO支架刺激犬II类根分叉病变中骨缺损的愈合。与未经处理的支架相比,GO支架植入,牙周支持组织(包括牙槽骨、牙周韧带样组织和牙骨质样组织)形成明显增加。

综上所述,该研究结果表明,GO支架具有生物相容性,并具有优异的骨和牙周组织形成能力。因此,GO支架或可用于牙周组织工程。

原始出处:

Kohei Kawamoto, Hirofumi Miyaji, et al., Characterization and evaluation of graphene oxide scaffold for periodontal wound healing of class II furcation defects in dog. Int J Nanomedicine. 2018; 13: 2365–2376. doi:  10.2147/IJN.S163206

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    2018-05-22 1e16d8a5m40(暂无匿称)

    学习了

    0

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