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Autism Res:塑化剂双酚A暴露与儿童自闭症相关

2015-03-06 伊文 生物谷

塑料容器 Plastic bottles and containers (stock image). Credit: © photka / Fotolia   一项在线发表在Autism Research杂志上的研究首次报道了塑化剂双酚A(BPA)与儿童自闭症谱系障碍具有相关性。在这项研究中,来自罗文大学和罗格斯大学的研究人员发现BPA在ASD儿童体内并不能很好地

塑料容器 Plastic bottles and containers (stock image).

Credit: © photka / Fotolia  

一项在线发表在Autism Research杂志上的研究首次报道了塑化剂双酚ABPA)与儿童自闭症谱系障碍具有相关性。在这项研究中,来自罗文大学和罗格斯大学的研究人员发现BPA在ASD儿童体内并不能很好地代谢排出。

人们对BPA是否影响自闭症这一问题已经关注很多年,但之前一直没有直接证据证明其中的联系。该项研究的研究人员证明了BPA与自闭症之的确存在联系,BPA在自闭症儿童体内的代谢与其在健康儿童体内的代谢情况不同。

研究人员收集了46名ASD儿童和52名健康儿童的尿液样本,检测游离BPA和总的BPA浓度。BPA类似于许多其他化合物,当其与肝脏中的葡萄糖结合在一起就会发生醛糖酸化变成水溶性物质。对于机体来说,通过尿液中的葡糖苷酸进行排出是机体排出毒性物质的一条主要途径。

研究人员也进行了代谢组学分析,筛选儿童尿液中的化合物,结果表明ASD儿童尿液中检测到的化合物与排泄出的总的BPA的显著关联系性数值是对照组儿童的大约3倍,而与结合形式BPA的显著关联性数值比对照组儿童高出15倍。

在之前一些研究中发现,BPA能够作为内分泌干扰物发挥作用,而这项研究第一次在人类中证明了这一结论,并且第一次证明了BPA与自闭症具有一定相关性。这些观察结果表明,对部分儿童来说,其中间代谢结合BPA的能力可能与自闭症存在某种关系。

这项研究虽然只包括一小部分研究对象,但关键在于其在BPA与自闭症之间建立起联系,并为进一步研究敞开了窗口。根据这一研究结果,降低BPA的摄入或对孕妇及自闭症儿童有一定益处。

原始出处:

T. Peter Stein1,*, Margaret D. Schluter1, Robert A. Steer2, Lining Guo3,4 andXue Ming5.Bisphenol A Exposure in Children With Autism Spectrum Disorders.Autism Research.13 JAN 2015.DOI: 10.1002/aur.1444


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    2015-03-24 zzc2224
  3. [GetPortalCommentsPageByObjectIdResponse(id=2009365, encodeId=cba12009365f1, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Jan 27 14:22:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775136, encodeId=6c2b1e75136d4, content=<a href='/topic/show?id=b6f5422051e' target=_blank style='color:#2F92EE;'>#塑化剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42205, encryptionId=b6f5422051e, topicName=塑化剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b1738750708, createdName=zzc2224, createdTime=Tue Mar 24 09:22:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071311, encodeId=056b20e131154, content=<a href='/topic/show?id=b5d2300622' target=_blank style='color:#2F92EE;'>#autism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3006, encryptionId=b5d2300622, topicName=autism)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Wed Dec 16 19:22:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17927, encodeId=2ca71e927c5, content=国内瑞金医院宁光教授一直关注。认为还可以引发糖尿病。儿童奶瓶,水杯尽量用安全的,少用塑料杯, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Mar 08 10:35:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350096, encodeId=3e1d1350096a3, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527584, encodeId=247d152e584d5, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17892, encodeId=effa1e8926b, content=天啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sat Mar 07 21:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=)]
    2015-12-16 xuyu
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    2015-03-08 223.104.5.**

    国内瑞金医院宁光教授一直关注。认为还可以引发糖尿病。儿童奶瓶,水杯尽量用安全的,少用塑料杯

    0

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    2015-03-08 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=2009365, encodeId=cba12009365f1, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Jan 27 14:22:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775136, encodeId=6c2b1e75136d4, content=<a href='/topic/show?id=b6f5422051e' target=_blank style='color:#2F92EE;'>#塑化剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42205, encryptionId=b6f5422051e, topicName=塑化剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b1738750708, createdName=zzc2224, createdTime=Tue Mar 24 09:22:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071311, encodeId=056b20e131154, content=<a href='/topic/show?id=b5d2300622' target=_blank style='color:#2F92EE;'>#autism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3006, encryptionId=b5d2300622, topicName=autism)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Wed Dec 16 19:22:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17927, encodeId=2ca71e927c5, content=国内瑞金医院宁光教授一直关注。认为还可以引发糖尿病。儿童奶瓶,水杯尽量用安全的,少用塑料杯, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Mar 08 10:35:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350096, encodeId=3e1d1350096a3, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527584, encodeId=247d152e584d5, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17892, encodeId=effa1e8926b, content=天啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sat Mar 07 21:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=)]
    2015-03-08 xiongke014
  7. [GetPortalCommentsPageByObjectIdResponse(id=2009365, encodeId=cba12009365f1, content=<a href='/topic/show?id=df47284508e' target=_blank style='color:#2F92EE;'>#儿童自闭症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28450, encryptionId=df47284508e, topicName=儿童自闭症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Jan 27 14:22:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775136, encodeId=6c2b1e75136d4, content=<a href='/topic/show?id=b6f5422051e' target=_blank style='color:#2F92EE;'>#塑化剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42205, encryptionId=b6f5422051e, topicName=塑化剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7b1738750708, createdName=zzc2224, createdTime=Tue Mar 24 09:22:00 CST 2015, time=2015-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071311, encodeId=056b20e131154, content=<a href='/topic/show?id=b5d2300622' target=_blank style='color:#2F92EE;'>#autism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3006, encryptionId=b5d2300622, topicName=autism)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Wed Dec 16 19:22:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17927, encodeId=2ca71e927c5, content=国内瑞金医院宁光教授一直关注。认为还可以引发糖尿病。儿童奶瓶,水杯尽量用安全的,少用塑料杯, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Sun Mar 08 10:35:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350096, encodeId=3e1d1350096a3, content=<a href='/topic/show?id=dbd33e6226c' target=_blank style='color:#2F92EE;'>#双酚A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37622, encryptionId=dbd33e6226c, topicName=双酚A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527584, encodeId=247d152e584d5, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Sun Mar 08 04:22:00 CST 2015, time=2015-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17892, encodeId=effa1e8926b, content=天啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Sat Mar 07 21:02:00 CST 2015, time=2015-03-07, status=1, ipAttribution=)]
    2015-03-07 xiaoai5777

    天啊

    0

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