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Sci Rep:术前%p2PSA和前列腺健康指数能够预测根治性前列腺切除前列腺癌患者的病理结果

2020-02-03 AlexYang MedSci原创

最近,有研究人员评估了%p2PSA和前列腺健康指数(PHI)在预测经历根治性前列腺切除术(RP)前列腺癌(PCa)患者的侵袭性病理结果的预测准确性情况。研究人员招募了91名器官受限的PCa患者,他们均经历了机器人辅助的RP治疗。之后,研究人员调查了p2PSA水平和PHI在预测病理性结果方面的能力。研究发现,%p2PSA和PHI在≥pT3疾病、高风险疾病和阳性手术切缘以及精囊浸润(SVI)的患者中显

最近,有研究人员评估了%p2PSA和前列腺健康指数(PHI)在预测经历根治性前列腺切除术(RP)前列腺癌(PCa)患者的侵袭性病理结果的预测准确性情况。

研究人员招募了91名器官受限的PCa患者,他们均经历了机器人辅助的RP治疗。之后,研究人员调查了p2PSA水平和PHI在预测病理性结果方面的能力。研究发现,%p2PSA和PHI在≥pT3疾病、高风险疾病和阳性手术切缘以及精囊浸润(SVI)的患者中显著更高。在单变量分析中,p2PSA衍生物是≥pT3疾病、高风险疾病和阳性手术切缘以及精囊浸润(SVI)的显著预测因子。为了预测不良病理结果的敏感性为90%,p2PSA衍生物要比标准PSA衍生物具有更高的特异性。在多变量分析中,≥pT3疾病、高风险疾病和阳性手术切缘的p2PSA水平和PHI的AUC面积具有额外的增加(分别为8.2%和2.7%, 6.2% 和4.1%, 8.6%和5.4%)。另外,PHI≥61.26能够通过增加AUC(0.624到0.819)来增强模型SVI的预测准确性(p=0.009)。

最后,研究人员指出,术前%p2PSA和PHI能够准确的预测不良病理结果,并对治疗决策是有用的。

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    2020-02-05 jeanqiuqiu
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    2020-02-03 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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