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大剂量甲氨蝶呤亚叶酸钙解救疗法治疗恶性肿瘤专家共识

2019-10-30 中国临床肿瘤学会 中国肿瘤临床.2019,46(15):761-767.

大剂量甲氨蝶呤亚叶酸钙解救(high dose methotrexate-calciumfolinate-rescue,HD-MTX-CFR)疗法中应用的MTX剂量属于致死量,在增加细胞毒作用提高抗肿瘤疗效的同时,也会出现极为严重的骨髓抑制及多脏器功能衰竭等损伤,合理的甲酰四氢叶酸钙(calcium folinate,CF)解救和水化碱化显得尤为关键。为提高HD-MTX化疗的临床疗效和安全性,规范

中文标题:

大剂量甲氨蝶呤亚叶酸钙解救疗法治疗恶性肿瘤专家共识

发布机构:

中国临床肿瘤学会

发布日期:

2019-10-30

简要介绍:

大剂量甲氨蝶呤亚叶酸钙解救(high dose methotrexate-calciumfolinate-rescue,HD-MTX-CFR)疗法中应用的MTX剂量属于致死量,在增加细胞毒作用提高抗肿瘤疗效的同时,也会出现极为严重的骨髓抑制及多脏器功能衰竭等损伤,合理的甲酰四氢叶酸钙(calcium folinate,CF)解救和水化碱化显得尤为关键。为提高HD-MTX化疗的临床疗效和安全性,规范CF解救的剂量和时间,中国临床肿瘤学会(CSCO)、CSCO抗白血病联盟、CSCO抗淋巴瘤联盟在参考国内外循证医学资料和相关指南的基础上,结合临床实践编写了此共识,供血液科、肿瘤科及儿科医生参考。

 

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    2020-12-10 yumeng0126

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