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Brit J Cancer:首次绝经后出血是癌症风险的临床标志

2019-12-06 xing.T MedSci原创

由此可见,在丹麦人群中,首次被医院诊断为绝经后出血的妇女患妇科、泌尿系统、胃肠道和血液系统癌症的风险增加。子宫内膜癌、卵巢癌和膀胱癌的SIR在几年内均较高。

绝经后出血的长期癌症风险数据很少。近日,肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员使用丹麦医学注册机构中1995-2013年间首次经医院诊断为绝经后出血的妇女进行了人群研究。

研究人员计算了癌症的绝对危险度和标准化的发生率(SIR),并与普通人群的预期发病率进行了比较。

在43756名绝经后出血的女性中,子宫内膜癌1年和5年绝对风险分别为4.66%和5.18%。子宫内膜癌的SIR在0-3个月(SIR=330.36(95%CI为315.43-345.81))、3-12个月(SIR=11.39(95%CI为9.79-13.17))、1-5年(SIR=2.55(95%CI为2.19–2.94))和>5年(SIR=1.63(95%CI为1.40–1.90))的随访期间升高。所有选定的妇科、泌尿系统、肠道血液系统癌症的SIR在0-3个月内升高。随访一年后,卵巢癌和膀胱癌的SIR仍然升高,其1-5年SIR分别为2.15(95%CI为1.71-2.65)和1.45(95%CI为1.14-1.80)。

由此可见,在丹麦人群中,首次被医院诊断为绝经后出血的妇女患妇科、泌尿系统、肠道血液系统癌症的风险增加。子宫内膜癌、卵巢癌和膀胱癌的SIR在几年内均较高。 

原始出处:

Maria B. Bengtsen,et al.First-time postmenopausal bleeding as a clinical marker of long-term cancer risk: A Danish Nationwide Cohort Study.British Journal of Cancer.2019.https://www.nature.com/articles/s41416-019-0668-2

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