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J Bone Miner Res:钙和维生素D补充是否影响缺血性心脏事件或死亡风险?

2018-05-24 门鹏 环球医学网

2018年5月,英国和法国科学家在《J Bone Miner Res》发表了英国生物银行队列结果,表明钙和维生素D补充与缺血性心脏事件或死亡风险不相关。

2018年5月,英国和法国科学家在《J Bone Miner Res》发表了英国生物银行队列结果,表明钙和维生素D补充与缺血性心脏事件或死亡风险不相关。

研究者在基于人群的英国队列中,考察了钙/维生素D补充与心血管事件/死亡之间的相关性。英国生物银行是一个大型前瞻性队列,由502637例入组时为40~69岁的男性和女性组成。通过自我报告的形式提供钙/维生素D补充情况,缺血性心脏病(IHD)、心肌梗死(MI)和随后死亡的住院信息(ICD-10)从全国注册中获取。Cox成比例风险模型用于考察钙/维生素D补充与男性/女性住院之间的纵向相关性,并控制了协变量。

总共475255例参与者(中位年龄58岁,55.8%为女性)具有完整的钙/维生素D补充数据。其中,33437例参与者报告钙补充;19089例报告维生素D补充,10007例二者都补。在原始和调整分析中,钙补充剂使用与IHD或随后死亡的住院风险之间无相关性。因此,例如,在未调整模型中,服用钙补充剂的MI女性的住院风险比(HR)为0.97(95% 置信区间[CI],0.79~1.20;p=0.79)。男性相应的HR为1.16(95% CI,0.92~1.46;p=0.22)。全调整后,女性和男性的HR分别为0.82(95% CI,0.62~1.07;p=0.14)和1.12(95% CI,0.85~1.48;p=0.41)。女性和男性IHD住院的调整HR分别为1.05(95% CI,0.92~1.19;p=0.50)和0.97(95% CI,0.82~1.15;p=0.77)。维生素D和联合补充剂的结果相似。

钙和维生素D补充与死亡之间无相关性,在女性中,进一步调整了激素替代疗法的使用并不改变该相关性。在这项非常大型的前瞻性队列中,无证据显示钙/维生素D补充剂使用与缺血性心血管事件后住院或死亡风险增加相关。

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    2018-10-04 apoenzyme
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    2018-05-31 半夏微凉

    学习了谢谢分享

    0

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    2018-05-27 大爰

    好文章学习并分享!!

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=2036990, encodeId=95e72036990c0, content=<a href='/topic/show?id=cf6d51401d9' target=_blank style='color:#2F92EE;'>#心脏事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51401, encryptionId=cf6d51401d9, topicName=心脏事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5494471, createdName=HNYYM, createdTime=Thu Jun 21 15:23:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893055, encodeId=1b681893055bf, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Tue Jul 31 20:23:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1806974, encodeId=d65218069e4de, content=<a href='/topic/show?id=c590e9366ab' target=_blank style='color:#2F92EE;'>#缺血性心脏事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79366, encryptionId=c590e9366ab, topicName=缺血性心脏事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Dec 07 07:23:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915176, encodeId=1cb619151e6db, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Thu Oct 04 03:23:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320173, encodeId=ac593201e3aa, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 31 06:58:10 CST 2018, time=2018-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318890, encodeId=403131889010, content=好文章学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=2, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun May 27 06:46:43 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255766, encodeId=f8271255e6638, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sat May 26 05:23:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318417, encodeId=837731841e5b, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Fri May 25 10:03:58 CST 2018, time=2018-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=318359, encodeId=ce13318359da, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Fri May 25 07:27:18 CST 2018, time=2018-05-25, status=1, ipAttribution=)]
    2018-05-25 cscdliu

    学习了.谢谢

    0

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    2018-05-25 张新亮1853311252142e2fm

    好文献学习了

    0

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2018年4月,美国预防医学工作组(USPSTF)更新了关于补充维生素,钙或联合补充作为社区成人骨折的一级预防建议,该建议声明是对2013版的更新,USPSTF最后总结,当前证据不足以评估维生素D和钙的补充(单独或联合)的风险和获益。

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