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NEJM:慢性铅中毒的Burton线-病例报道

2018-11-08 xing.T MedSci原创

Burton线是慢性铅中毒的标志,当铅与口腔细菌代谢产物发生反应时就会形成这种标志。然后患者承认有10年的咀嚼鸦片史。对患者的鸦片样本进行分析,发现每1g鸦片中铅浓度为17mg。铅有时可能会添加到鸦片中以增加其重量。

患者为一名39岁的男性,因急性腹痛和便秘加剧4周而到急诊就诊。

腹部体格检查和腹部成像结果,包括超声检查和计算机断层扫描,显示正常。实验室检查显示血红蛋白水平为12.5g/dL(正常范围为14.0-17.5)。上消化道内镜检查和结肠镜检查结果正常。由于肠道症状的原因尚不清楚,因此检查了卟啉症相关实验室指标。24小时尿液检测显示δ氨基乙酰丙酸的排泄水平为每天545μmol(正常范围<49),并且血液中的铅水平显著升高至136μg/dl(6.55μmol/L)。



重复体格检查,并注意到沿着下牙龈边缘的灰线(称为Burton线)(如箭头所示)。Burton线是慢性铅中毒的标志,当铅与口腔细菌代谢产物发生反应时就会形成这种标志。然后患者承认有10年的咀嚼鸦片史。对患者的鸦片样本进行分析,发现每1g鸦片中铅浓度为17mg。铅有时可能会添加到鸦片中以增加其重量。

该患者接受了螯合剂治疗,并被告知口腔卫生的重要性;他也停止了咀嚼鸦片。在开始治疗后7个月的随访中,患者的腹痛和便秘已经消退,Burton线明显减轻。

原始出处:

Friederike Helmich,et al. Burton’s Line from Chronic Lead Intoxication.N Engl J Med 2018;https://www.nejm.org/doi/full/10.1056/NEJMicm1801693

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    2018-11-10 衣带渐宽

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    2018-11-09 mashirong
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